Sclerostin and bone turnover markers response to cycling and running at the same moderate-to-vigorous exercise intensity in healthy men

• Published in: Journal of endocrinological investigation Vol. 45; no. 2; pp. 391 - 397
• Main Authors: Dror, N., Carbone, J., Haddad, F., Falk, B., Klentrou, P., Radom-Aizik, S.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2022; Springer Nature B.V
• Subjects: Adaptor Proteins, Signal Transducing - analysis; Adaptor Proteins, Signal Transducing - blood; Adaptor Proteins, Signal Transducing - metabolism; Biomarkers - analysis; Biomarkers - blood; Biomarkers - metabolism; Bone and Bones - metabolism; Bone growth; Bone remodeling; Bone Remodeling - physiology; Bone resorption; Bone Resorption - metabolism; Bone turnover; Collagen (type I); Collagen Type I - blood; Correlation of Data; Endocrinology; Exercise intensity; Exercise Test - methods; Fibronectins - blood; Healthy Volunteers; Heart rate; Humans; Internal Medicine; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Original Article; Osteocalcin; Osteocalcin - blood; Osteogenesis; Osteogenesis - physiology; Parathyroid; Parathyroid hormone; Parathyroid Hormone - blood; Peptide Fragments - blood; Peptides - blood; Physical training; Procollagen - blood; Running; Running - physiology; SOST protein; Young Adult; Irisin; Sclerostin; Exercise; Bone; PTH
• ISSN: 1720-8386; 0391-4097; 1720-8386
• DOI: 10.1007/s40618-021-01659-5

Background Recreational cycling is a popular activity which stimulates and improves cardiovascular fitness. The corresponding benefits for bone are unclear. Purpose This study examined the effect of running (high-impact) vs. cycling (low-impact), at the same moderate-to-vigorous exercise intensity, on markers of bone formation (N-terminal propeptide of type I collagen, PINP) and bone resorption (C-telopeptide of type I collagen, CTX-1), a non-collagenous bone remodeling marker (osteocalcin), as well as bone-modulating factors, including parathyroid hormone (PTH), irisin (myokine) and sclerostin (osteokine). Methods Thirteen healthy men (23.7 ± 1.0 y) performed two progressive exercise tests to exhaustion (peak VO 2 ) on a cycle ergometer (CE) and on a treadmill (TM). On subsequent separate days, in randomized order, participants performed 30-min continuous running or cycling at 70% heart rate reserve (HRR). Blood was drawn before, immediately post- and 1 h into recovery. Results PTH transiently increased (CE, 51.7%; TM, 50.6%) immediately after exercise in both exercise modes. Sclerostin levels increased following running only (27.7%). Irisin increased following both running and cycling. In both exercise modes, CTX-1 decreased immediately after exercise, with no significant change in PINP and osteocalcin. Conclusion At the same moderate-to-vigorous exercise intensity, running appears to result in a greater transient sclerostin response compared with cycling, while the responses of bone markers, PTH and irisin are similar. The longer-term implications of this differential bone response need to be further examined.