Clinical characteristics, diagnosis and management of Sweet syndrome induced by azathioprine

• Published in: Clinical and experimental medicine Vol. 23; no. 7; pp. 3581 - 3587
• Main Authors: Fan, Zhiqiang, He, Yang, Sun, Wei, Li, Zuojun, Ye, Chao, Wang, Chunjiang
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.11.2023; Springer Nature B.V
• Subjects: Arthralgia; Azathioprine; C-reactive protein; Case reports; Diagnosis; Edema; Hematology; Internal Medicine; Leukocytes (neutrophilic); Medicine; Medicine & Public Health; Neutropenia; Oncology; Patients; Skin diseases; Skin lesions; Sweet's syndrome; Sweet syndrome; Neutrophilic dermatosis; Azathioprine; Drug reaction; Hypersensitivity
• ISSN: 1591-9528; 1591-8890; 1591-9528
• DOI: 10.1007/s10238-023-01135-9

Sweet syndrome is a rare complication of azathioprine treatment with unelucidated clinical features. The purpose of this study was to investigate the clinical characteristics of azathioprine-induced Sweet syndrome (AISS) and provide a reference for diagnosis, treatment and prognosis. We collected relevant case reports of AISS by searching Chinese and English databases from 1960 to December 31, 2022, extracted the data and carried out a retrospective analysis. The median age of the 44 patients was 50 (range 9–89) years, and they included 32 males (72.7%). Fever (86.4%) and arthralgia (31.8%) were the most common clinical symptoms. The skin lesions were mainly pustules (54.5%), papules (40.9%), plaques (40.9%) and nodules (31.8%), which were mainly distributed on the extremities (54.5%), face (38.6%) and hands (36.4%). Laboratory examination revealed neutropenia (65.9%) as well as elevated C-reactive protein (63.6%) and erythrocyte sedimentation (40.9%) rates. Histopathology of the lesioned skin showed neutrophil infiltration (93.2%) and dermal edema (38.6%). Symptom relief was achieved at a median time of 7 days (range 2–28 days) after azathioprine discontinuation in all patients. Nine patients (20.5%) had skin lesions that recurred within 24 h after taking azathioprine again. Clinicians and pharmacists should grasp the regularity and characteristics of AISS and should not recommend the readministration of azathioprine, to avoid the recurrence of Sweet syndrome.