Mesenchymal Stem Cell-Derived Extracellular Vesicles: The Novel Therapeutic Option for Regenerative Dentistry

Dental mesenchymal stem cells (MSCs) are characterized by unlimited self-renewal ability and high multidirectional differentiation potential. Since dental MSCs can be easily isolated and exhibit a high capability to differentiate into odontogenic cells, they are considered as attractive therapeutic...

Full description

Saved in:
Bibliographic Details
Published inStem cell reviews and reports Vol. 19; no. 1; pp. 46 - 58
Main Authors Kong, Haiying, Liu, Peiqi, Li, Hongwen, Zeng, Xiantao, Xu, Peiwu, Yao, Xinhui, Liu, Senqing, Cheng, Chak Kwong, Xu, Jian
Format Journal Article
LanguageEnglish
Published New York Springer US 2023
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Cell Biology
Cell differentiation
Cell interactions
Cell self-renewal
Cell- and Tissue-Based Therapy
Clinical medicine
Cytokines
Dentistry
Extracellular Vesicles
Growth factors
Life Sciences
Mesenchymal Stem Cells
Microenvironments
Osteogenesis - genetics
Phenotypes
Regenerative medicine
Regenerative Medicine/Tissue Engineering
Skin & tissue grafts
Stem Cells
Tissue engineering
Extracellular vesicles
Regenerative dentistry
miRNAs
Dental mesenchymal stem cells
Osteogenic differentiation
Online AccessGet full text

Cover

More Information
Summary:Dental mesenchymal stem cells (MSCs) are characterized by unlimited self-renewal ability and high multidirectional differentiation potential. Since dental MSCs can be easily isolated and exhibit a high capability to differentiate into odontogenic cells, they are considered as attractive therapeutic agents in regenerative dentistry. Recently, MSC-derived extracellular vesicles (MSC-EVs) have attracted widespread attention as carriers for cell-free therapy due to their potential functions. Many studies have shown that MSC-EVs can mediate microenvironment at tissue damage site, and coordinate the regeneration process. Additionally, MSC-EVs can mediate intercellular communication, thus affecting the phenotypes and functions of recipient cells. In this review, we mainly summarized the types of MSCs that could be potentially applied in regenerative dentistry, the possible molecular cargos of MSC-EVs, and the major effects of MSC-EVs on the therapeutic induction of osteogenic differentiation. Graphical abstract
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2629-3269
2629-3277
DOI:10.1007/s12015-022-10342-y