A Fluorescent Zn(II)-Coordination Polymer: Selective Detection of Nitrofurantoin and Prevention of Peri-Implantitis after Ultrafine-Grained Titanium Implant by Reducing Inflammatory Cytokines Release

• Published in: Journal of fluorescence Vol. 30; no. 5; pp. 1035 - 1042
• Main Authors: Liu, Mingda, Chi, Yanxia
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2020; Springer Nature B.V
• Subjects: Analytical Chemistry; Animals; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biomedicine; Biophysics; Biotechnology; Chemical analysis; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Coordination compounds; Coordination polymers; Cytokines; Cytokines - analysis; Cytokines - antagonists & inhibitors; Cytokines - metabolism; Dental Implants; Dogs; Fluorescence; Fluorescent Dyes - chemical synthesis; Fluorescent Dyes - chemistry; Fluorescent Dyes - pharmacology; Fourier transforms; Gingival Crevicular Fluid - metabolism; Imidazole; Infrared analysis; Infrared spectroscopy; Nitrofurantoin - analysis; Original Article; Polymers - chemistry; Polymers - pharmacology; Single crystals; Tetrazoles; Thermogravimetric analysis; Titanium - adverse effects; Ultrafines; Water Pollutants, Chemical - analysis; X ray powder diffraction; X-ray diffraction; Zinc - chemistry; Zinc - pharmacology; Zn-complex; Peri-implantitis; Coordination polymer; Nitrofurantoin detection; Bifunctional ligand
• ISSN: 1053-0509; 1573-4994
• DOI: 10.1007/s10895-020-02575-2

In the current research, a novel coordination polymer (CP) containing Zn(II) ions as nodes with the chemical formula of [Zn(IPT) 2 ] n ( 1 ) has been produced via reaction of Zn(NO 3 ) 2 ·6H 2 O with 5-(3-(1H-imidazol-1-yl)phenyl)-1H-tetrazolate (HIPT), a heterotopic imidazole-tetrazole-bifunctional ligand. The as-prepared complex 1 has been charactered via single crystal X-ray diffraction, elemental analysis, powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA) and fourier transform infrared spectroscopy (FT-IR). Because of its outstanding luminescent performances and stability, the synthesized complex 1 is a kind of excellent material of luminescent sensor of nitrofurantoin (NFT) in the water. The value of K sv for the complex 1 to NFT is about 1.4 × 10 4  M −1 . For the treatment of the peri-implantitis with complex 1 , the ELISA test was carried out to determine the levels of the inflammatory cytokines released into the gingival crevicular fluid. The results showed that the levels of the inflammatory cytokines could be significantly reduced by complex 1 treatment. In addition to this, the real time RT-PCR was also conducted, and the data suggested the signaling pathway of TLR-4-NF-κB activation was inhibited by complex 1 .