Serum decoy receptor 3 (DcR3): a promising biomarker for atopic asthma in children

• Published in: Immunologic research Vol. 69; no. 6; pp. 568 - 575
• Main Authors: Kamal, Asmaa, Abdelmegeid, Azza K., Gabr, Maha A. M., Basanti, Christine W. S.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2021; Springer Nature B.V
• Subjects: Allergology; Asthma; Asthma - blood; Asthma - immunology; Atopy; Biomarkers; Biomarkers - blood; Biomedical and Life Sciences; Biomedicine; Child; Children; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunology; Inflammatory diseases; Internal Medicine; Male; Medicine/Public Health; Morbidity; Original Article; Patients; Pediatrics; Receptors; Receptors, Tumor Necrosis Factor, Member 6b - blood; Receptors, Tumor Necrosis Factor, Member 6b - immunology; DcR3; TNFRS; Bronchial asthma; Biomarker; Inflammatory diseases
• ISSN: 0257-277X; 1559-0755
• DOI: 10.1007/s12026-021-09218-z

Bronchial asthma is a common chronic inflammatory disease with high prevalence and morbidity, particularly in school-aged children. Decoy receptor 3 (DcR3) is a soluble decoy receptor that belongs to the tumor necrosis factor receptor superfamily and has been reported to be elevated in several allergic and inflammatory diseases. This study was designed to determine the role of DcR3 in pediatric asthma. The serum DcR3 levels were analyzed in 85 subjects (60 pediatric patients with bronchial asthma and 25 age- and sex-matched healthy control children) using the enzyme-linked immunosorbent assay technique. Patients with asthma had higher serum DcR3 levels than healthy control subjects ( p  = 0.007). In the atopic group of patients with asthma, the serum DcR3 levels were inversely correlated with the asthma control test score ( R  =  − 0.392, p  = 0.039). Overall, DcR3 could be a promising biomarker of atopic asthma, specifically in pediatric patients.