Case–Control Study of 3D Morphology in Isolated Mesenteric Artery Dissection

• Published in: Cardiovascular engineering and technology Vol. 14; no. 2; pp. 230 - 238
• Main Authors: Ben Abdallah, Iannis, Craiem, Damian, Casciaro, Mariano, Deza, Damian, Ronot, Maxime, Corcos, Olivier, Castier, Yves, El Batti, Salma
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2023; Springer Nature B.V
• Subjects: Aortic Dissection - diagnostic imaging; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedical Engineering/Biotechnology; Biomedicine; Body size; Cardiology; Case-Control Studies; Diameters; Dissection; Female; Humans; Ischemia; Male; Mesenteric Arteries; Mesenteric Ischemia - diagnostic imaging; Middle Aged; Morphology; Original Article; Retrospective Studies; Treatment Outcome; Volumetric analysis; Mesenteric artery dissection; 3D morphology; Aortomesenteric angle
• ISSN: 1869-408X; 1869-4098
• DOI: 10.1007/s13239-022-00649-9

Introduction Isolated mesenteric artery dissection (IMAD) is uncommon and has not been investigated in detail. This study aimed to accurately identify the morphological differences of IMAD patients with control individuals using a detailed 3D volumetric analysis. Methods In this retrospective case–control study, cases were patients with acute symptomatic IMAD treated in a French intestinal stroke center between January 2016 and November 2019. Case–control matching was (1:3) by age, gender, and body mass index (BMI). The semi-automatic morphological analysis of the mesenteric artery included volumetric measurements of the true and false lumen size, the centerline curvature and the 3D aortomesenteric angles. Results Seventeen IMAD cases (mean age 56 ± 4 years, 94% men) were matched with 51 controls. The mean overall lumen (OL) volume was higher in IMAD patients as compared to controls (+ 64%, p  < 0.001). In the same way, the mean OL cross-sectional area and diameters were higher in IMAD patients: + 77% for OL area (< 0.001) and + 34% for OL diameters (< 0.001). Meanwhile, no significant difference was found in terms of true lumen (TL) volume ( p  = 0.16) or cross-sectional area ( p  = 0.30) between IMAD patients and controls, whereas the mean TL diameter was lower in the IMAD group ( p  < 0.05). Patients with acute mesenteric ischemia had a lower [TL/OL volume] ratio (45% vs. 59%, p  < 0.05) and longer dissections (63 mm vs. 48 mm, p  < 0.01). The 3D aortomesenteric angle was significantly higher in IMAD patients at both 2 cm ( p  < 0.01) and 4 cm ( p  < 0.05) from the ostium. Conclusion Using an original 3D semi-automated analysis, this study shows that IMAD induces significant morphological changes compared to control individuals: a larger aortomesenteric 3D angle, an increased overall volume and area. IMAD patients with acute mesenteric ischemia presented with a more severe morphological profile.