A giant superinfected uterine angioleiomyoma with distant septic metastases: an extremely rare presentation of a benign process and a systematic review of the literature

• Published in: Archives of gynecology and obstetrics Vol. 300; no. 4; pp. 841 - 847
• Main Authors: Sánchez-Iglesias, José-Luis, Capote, Sira, Cubo-Abert, Montserrat, Carbonell-Socias, Melchor, Cabrera, Silvia, Illán-Hernández, Lidia, Pérez-Benavente, Maria-Assumpció, Monreal-Clua, Sonia, Gil-Moreno, Antonio
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2019; Springer Nature B.V
• Subjects: Angiomyoma - complications; Angiomyoma - pathology; Biopsy; Endocrinology; Female; Fibroids; Gynecology; Human Genetics; Humans; Hysterectomy; Medicine; Medicine & Public Health; Metastasis; Middle Aged; Neoplasm Metastasis; Neoplasms; Obstetrics/Perinatology/Midwifery; Review; Sarcoma; Sepsis - etiology; Sepsis - pathology; Uterine Neoplasms - complications; Uterine Neoplasms - pathology; Uterine angioleiomyoma; Endometrial stroma sarcoma; Septic distant metastases; Immunohistochemical study
• ISSN: 0932-0067; 1432-0711
• DOI: 10.1007/s00404-019-05267-w

Purpose Uterine angioleiomyoma is a rare type of leiomyoma variant and there are few cases reported in the literature. The definitive diagnosis is usually obtained only after the histopathologic examination because there are no specific imaging criteria for this disease. The objective of this article is to review published cases about this clinical condition. Methods We report a case of giant angioleiomyoma superinfected by S. agalactiae with the development of latero-cervical distant metastasis in a premenopausal woman. Firstly, the case herein reported was orientated as an endometrial stroma sarcoma in the peri-operative histologic examination by frozen sections. It was treated with laparotomic total hysterectomy, bilateral salpingo-oophorectomy, inframesocolic omentectomy and pelvic and paraaortic lymph node dissection. Postoperative definitive anatomopathological analyses using a proper immunohistochemical panel revealed a case of uterine angioleiomyoma. We also review other case reports published about this clinical condition. Results We present the first case reported in the literature, in our knowledge, of a giant angioleiomyoma superinfected by S. agalactiae with the development of distant septic metastases. Immunohistochemistry permitted the definitive diagnosis of angioleiomyoma. Treatments previously reported are hysterectomy or tumor resection and any patient recurred. Conclusions The definitive diagnosis is usually obtained after the definitive histopathologic examination since the use of immunohistochemical study has an important role in this regard. Complete surgical removal of the lesion is the treatment of choice, with no recurrent cases reported to date.