Estimation of renal function using kidney dynamic contrast material-enhanced CT perfusion: accuracy and feasibility

• Published in: Abdominal imaging Vol. 46; no. 5; pp. 2045 - 2051
• Main Authors: Jeong, Seokmin, Park, Sung Bin, Chang, In Ho, Shin, Jungho, Chi, Byung Hoon, Park, Hyun Jeong, Lee, Eun Sun
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2021; Springer Nature B.V
• Subjects: Bladder; Computed tomography; Contrast agents; Correlation analysis; Correlation coefficient; Correlation coefficients; Epidermal growth factor receptors; Feasibility; Gastroenterology; Hepatology; Imaging; Kidneys; Mathematical analysis; Medicine; Medicine & Public Health; Perfusion; Permeability; Radiology; Renal function; Retroperitoneum; Statistical analysis; Tomography; Ureters; Urography; Tomography; Spiral computed; Perfusion imaging; X-ray computed; Glomerular filtration rate
• ISSN: 2366-004X; 2366-0058
• DOI: 10.1007/s00261-020-02826-7

Purpose To measure glomerular filtration rates (GFRs) using kidney dynamic contrast material-enhanced (DCE)-CT perfusion scans and correlate them with estimated GFRs (eGFRs). Materials and methods Split-bolus CT urography, including pre-contrast and nephrographic-excretory phase imaging, was performed with a kidney DCE-CT perfusion scan protocol. We analysed 55 patients with suspected renal disease. All CT acquisitions were obtained on a 256-slice CT scanner for 3.5 min continuously with shallow breathing. Renal volume, perfusion and permeability values were calculated using a dedicated prototype software. Based on Patlak plots, split and total renal GFR values were determined. Paired t-tests, Pearson’s correlation analysis and Bland-Altman plots were used for comparisons between kidney DCE-CT perfusion scan-derived GFR (CT-GFR) and the corresponding eGFR value. The p values < 0.05 were considered statistically significant. Results The mean CT-GFR was 91.19 ± 20.71 mL/min/1.73 m 2 . The eGFR values based on the CKD-EPI and MDRD equations were 89.64 ± 19.74 mL/min/1.73 m 2 and 89.50 ± 24.89 mL/min/1.73 m 2 , respectively. No statistically significant differences were found between CT-GFR and eGFRs ( p > 0.05). Excellent correlation and agreement between CT-GFR and eGFRs (correlation coefficient r = 0.91 for CKD-EPI and 0.84 for MDRD equations, respectively) were confirmed. Conclusion Kidney DCE-CT perfusion is an accurate and feasible technique to assess renal function.