Effect of stereotactic radiotherapy on immune microenvironment of lung cancer

Stereotactic radiotherapy (SRT) is one of the main treatment modalities for lung cancer, and the current SRT approach combined with immunotherapy has initially presented good clinical efficacy in lung cancer. SRT activates the immune system through in situ immunization, releasing antigens into the b...

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Bibliographic Details
Published inFrontiers in immunology Vol. 13; p. 1025872
Main Authors Xiao, Yao, Zhuang, Hongqing
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 23.09.2022
Subjects
hypofractionated radiotherapy (HFRT)
immune microenvironment
Immunology
immunotherapy
lung cancer
SBRT
stereotactic radiotherapy
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Summary:Stereotactic radiotherapy (SRT) is one of the main treatment modalities for lung cancer, and the current SRT approach combined with immunotherapy has initially presented good clinical efficacy in lung cancer. SRT activates the immune system through in situ immunization, releasing antigens into the blood, which promotes the antigen–antibody response and then induces tumor cell apoptosis. Dose fractionation has different effects on the immune microenvironment, and the tumor microenvironment after SRT also changes over time, all of which have an impact on SRT combined immunotherapy. Although much research on the immune microenvironment of SRT has been conducted, many problems still require further exploration.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
Reviewed by: Feng Liu, Hunan Cancer Hospital, Central South University, China; Siyu Shi, Stanford Healthcare, United States
Edited by: Huanfa Yi, Jilin University, China
This article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.1025872