Ultrashort echo time magnetization transfer imaging of knee cartilage and meniscus after long-distance running

• Published in: European radiology Vol. 33; no. 7; pp. 4842 - 4854
• Main Authors: Zhu, Dantian, Wu, Wenhao, Yu, Wenjun, Hong, Guobin, Fang, Yijie, Li, Shaolin, Ma, Yajun
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2023; Springer Nature B.V
• Subjects: Cartilage; Cartilage, Articular - diagnostic imaging; Change detection; Diagnostic Radiology; Humans; Imaging; Internal Medicine; Interventional Radiology; Knee; Knee Joint - diagnostic imaging; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetization; Marathons; Medicine; Medicine & Public Health; Meniscus; Meniscus - diagnostic imaging; Musculoskeletal; Neuroradiology; Prospective Studies; Radiology; Reliability; Reproducibility; Reproducibility of Results; Running; Ultrasound; Menisci, tibial; Knee joint; Magnetic resonance imaging; Cartilage, articular; Marathon running
• ISSN: 1432-1084; 0938-7994; 1432-1084
• DOI: 10.1007/s00330-023-09462-x

Objective To assess the detection of changes in knee cartilage and meniscus of amateur marathon runners before and after long-distance running using a 3D ultrashort echo time MRI sequence with magnetization transfer preparation (UTE-MT). Methods We recruited 23 amateur marathon runners (46 knees) in this prospective cohort study. MRI scans using UTE-MT and UTE-T2* sequences were performed pre-race, 2 days post-race, and 4 weeks post-race. UTE-MT ratio (UTE-MTR) and UTE-T2* were measured for knee cartilage (eight subregions) and meniscus (four subregions). The sequence reproducibility and inter-rater reliability were also investigated. Results Both the UTE-MTR and UTE-T2* measurements showed good reproducibility and inter-rater reliability. For most subregions of cartilage and meniscus, the UTE-MTR values decreased 2 days post-race and increased after 4 weeks of rest. Conversely, the UTE-T2* values increased 2 days post-race and decreased after 4 weeks. The UTE-MTR values in lateral tibial plateau, central medial femoral condyle, and medial tibial plateau showed a significant decrease at 2 days post-race compared to the other two time points ( p  < 0.05). By comparison, no significant UTE-T2* changes were found for any cartilage subregions. For meniscus, the UTE-MTR values in medial posterior horn and lateral posterior horn regions at 2 days post-race were significantly lower than those at pre-race and 4 weeks post-race ( p  < 0.05). By comparison, only the UTE-T2* values in medial posterior horn showed a significant difference. Conclusions UTE-MTR is a promising method for the detection of dynamic changes in knee cartilage and meniscus after long-distance running. Key Points • Long-distance running causes changes in the knee cartilage and meniscus. • UTE-MT monitors dynamic changes of knee cartilage and meniscal non-invasively. • UTE-MT is superior to UTE-T2* in monitoring dynamic changes in knee cartilage and meniscus.