Cell adhesion molecules, plasminogen activator inhibitor type 1, and metabolic syndrome in patients with psoriasis

• Published in: Clinical and experimental medicine Vol. 20; no. 1; pp. 39 - 48
• Main Authors: Teixeira, Guilherme Gomes, Mari, Naiara Lourenço, de Paula, Jaqueline Costa Castardo, Cataldi de Alcantara, Camila, Flauzino, Tamires, Lozovoy, Marcell Alysson Batisti, Martin, Ligia Márcia Mário, Reiche, Edna Maria Vissoci, Maes, Michael, Dichi, Isaias, Simão, Andréa Name Colado
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2020; Springer Nature B.V
• Subjects: Biomarkers; Carbohydrate metabolism; CD31 antigen; Cell adhesion & migration; Cell adhesion molecules; Diagnosis; E-selectin; Endothelial cells; Glucose metabolism; Hematology; Insulin; Intercellular adhesion molecule 1; Internal Medicine; Medicine; Medicine & Public Health; Metabolic syndrome; Oncology; Original Article; P-selectin; Plasma levels; Plasminogen activator inhibitors; Psoriasis; Vascular cell adhesion molecule 1; Carbohydrate metabolism; Plasminogen activator inhibitor type 1; Psoriasis; Metabolic syndrome; Cellular adhesion molecules
• ISSN: 1591-8890; 1591-9528; 1591-9528
• DOI: 10.1007/s10238-019-00595-2

The objective of this study is to delineate the cellular adhesion molecule (CAM) profile and plasminogen activator inhibitor type 1 (PAI-1), and their association with metabolic syndrome (MetS) and carbohydrate metabolism biomarkers in psoriasis patients with mild and moderate severity. Sixty-seven patients with psoriasis as well as 102 healthy subjects were recruited. Insulin and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), but not glucose, were significantly higher in psoriasis than in controls. Psoriasis was characterized by increased plasma levels of platelet endothelial cell adhesion molecule 1 (PECAM-1), vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), E-selectin, and PAI-1 as compared with controls. Psoriasis diagnosis could explain 59.0% of CAM and PAI-1 variance, with a particularly strong impact on E-selectin (45.6%), VCAM-1 (32.7%), and PAI-1 (24.8%). Subjects with MetS showed significantly higher E-selectin and PAI-1 than those without MetS. Using VCAM-1, E-selectin, PAI-1 (all positively), and P-selectin (inversely) in a binary regression equation, it was found that 87.6% of all patients were correctly classified with a sensitivity of 92.5% and a specificity of 84.3%. CAM and PAI-1 were correlated with carbohydrate metabolism biomarkers (glucose, insulin, and HOMA-IR). In conclusion, CAM levels are associated with psoriasis diagnosis and MetS may influence E-selectin and PAI-1 concentrations. More studies are needed to verify the causality among these factors, as well as their relation to the different degrees of disease severity.