Cost-Effectiveness Analysis of Erenumab Versus OnabotulinumtoxinA for Patients with Chronic Migraine Attacks in Greece

• Published in: Clinical drug investigation Vol. 39; no. 10; pp. 979 - 990
• Main Authors: Giannouchos, Theodoros V., Mitsikostas, Dimos-Dimitrios, Ohsfeldt, Robert L., Vozikis, Athanassios, Koufopoulou, Paraskevi
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.10.2019; Springer Nature B.V
• Subjects: Absenteeism; Adult; Analgesics; Antibodies, Monoclonal, Humanized - administration & dosage; Antibodies, Monoclonal, Humanized - economics; Botulinum Toxins, Type A - administration & dosage; Botulinum Toxins, Type A - economics; Calcitonin Gene-Related Peptide Receptor Antagonists - administration & dosage; Calcitonin Gene-Related Peptide Receptor Antagonists - economics; Chronic Disease; Clinical trials; Cost analysis; Cost-Benefit Analysis - methods; Decision Trees; Double-Blind Method; Economics; FDA approval; Female; Greece - epidemiology; Humans; Internal Medicine; Male; Medicine; Medicine & Public Health; Middle Aged; Migraine; Migraine Disorders - drug therapy; Migraine Disorders - economics; Migraine Disorders - epidemiology; Monoclonal antibodies; Nonsteroidal anti-inflammatory drugs; Original Research Article; Patients; Pharmacology/Toxicology; Pharmacotherapy; Prevention; Quality-Adjusted Life Years; Sensitivity analysis; Greece
• ISSN: 1173-2563; 1179-1918
• DOI: 10.1007/s40261-019-00827-z

Background Migraine is a common, chronic neurovascular brain disorder with non-negligible multifaceted economic costs. Existing preventive treatments involve the selective use of onabotulinumtoxinA, which aims at migraine morbidity reduction for patients who have failed initial preventive treatment with oral agents. Erenumab is a new preventive treatment for migraines. Objective To evaluate the differences in costs and outcomes of the preventive treatment with erenumab versus onabotulinumtoxinA in patients with chronic migraines (CM) in Greece to assess the economic value of this treatment. Methods We conducted a cost-effectiveness analysis from both the payer and the societal perspective using a decision-tree analytic model. Outcomes were expressed in migraines avoided and in quality-adjusted life-years (QALYs). We obtained model inputs from the existing literature. The decision path adjusted for variation in the probability of adherence and the resulting differential effectiveness between the two treatments. Direct costs included the cost of the two drugs and administration costs, the costs of acute drugs used under usual care, and the costs of hospitalization, physician, and emergency department visits. Indirect costs for the societal perspective analyses included wages lost on workdays. The time-horizon of the analysis was 1 year and all costs were calculated in 2019 euros (€). Sensitivity analyses were conducted to control for parameter uncertainty and to evaluate the robustness of the findings. Results Our results indicate that treatment of CM with erenumab compared to onabotulinumtoxinA resulted in incremental cost-effectiveness ratios (ICERs) of €218,870 and €231,554 per QALY gained and €620 and €656 per migraine avoided, from the societal and the payer’s perspective, respectively. Using a common cost-effectiveness threshold equal to three times the local gross domestic product (GDP) per capita (€49,000), for the erenumab ICERs to fall below this threshold, the erenumab price would have to be no more than €192 (societal perspective) or €173 (payer perspective). Conclusion The prophylactic treatment of CM with erenumab in Greece might be cost effective compared to the existing alternative of onabotulinumtoxinA from both the payer and the societal perspective, but only at a highly discounted price. Nevertheless, erenumab could be considered a therapeutic option for patients who fail treatment with onabotulinumtoxinA.