Using temperature to analyze the neural basis of a time-based decision

• Published in: Nature neuroscience Vol. 26; no. 8; pp. 1407 - 1416
• Main Authors: Monteiro, Tiago, Rodrigues, Filipe S, Pexirra, Margarida, Cruz, Bruno F, Gonçalves, Ana I, Rueda-Orozco, Pavel E, Paton, Joseph J
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.08.2023
• Subjects: Basal ganglia; Decision analysis; Decision making; Evolution; Ganglia; Kinematics; Motor task performance; Neostriatum; Temperature effects
• ISSN: 1097-6256; 1546-1726
• DOI: 10.1038/s41593-023-01378-5

The basal ganglia are thought to contribute to decision-making and motor control. These functions are critically dependent on timing information, which can be extracted from the evolving state of neural populations in their main input structure, the striatum. However, it is debated whether striatal activity underlies latent, dynamic decision processes or kinematics of overt movement. Here, we measured the impact of temperature on striatal population activity and the behavior of rats, and compared the observed effects with neural activity and behavior collected in multiple versions of a temporal categorization task. Cooling caused dilation, and warming contraction, of both neural activity and patterns of judgment in time, mimicking endogenous decision-related variability in striatal activity. However, temperature did not similarly affect movement kinematics. These data provide compelling evidence that the timecourse of evolving striatal activity dictates the speed of a latent process that is used to guide choices, but not continuous motor control. More broadly, they establish temporal scaling of population activity as a likely neural basis for variability in timing behavior.