Pulmonary nodular lymphoid hyperplasia and Sjögren’s syndrome: a case report and literature review

• Published in: Rheumatology international Vol. 41; no. 11; pp. 2041 - 2044
• Main Authors: Darder, Aina, Losada Lopez, Ines, Gomez-Bellvert, Cristina, Rodriguez, Adrian, Cisneros, Eugenia, Gonzalez-Moreno, Juan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2021; Springer Nature B.V
• Subjects: Adult; Aged; Case Based Review; Case reports; Diagnosis, Differential; Female; Humans; Hyperplasia; Literature reviews; Lung Diseases - complications; Lung Diseases - diagnostic imaging; Lung Diseases - pathology; Male; Medicine; Medicine & Public Health; Middle Aged; Positron Emission Tomography Computed Tomography; Pseudolymphoma - complications; Pseudolymphoma - diagnostic imaging; Pseudolymphoma - pathology; Rheumatology; Sjogren's Syndrome - complications; Sjogren's Syndrome - diagnosis; Sjögren’s syndrome; Lymphocytoma; Reactive lymphoid hyperplasia; Pseudolymphoma
• ISSN: 0172-8172; 1437-160X
• DOI: 10.1007/s00296-021-04915-2

Pulmonary nodular lymphoid hyperplasia, also known as pseudolymphoma, is an uncommon reactive lymphoproliferative disorder of unknown etiology that can be found in Sjögren’s syndrome patients. Here, we present a case of a previously healthy woman in which the incidental finding of a lung mass compatible with nodular lymphoid hyperplasia led to the subsequent diagnosis of Sjögren’s syndrome. We also performed a literature review for the association between both entities and described the main clinical aspects of the reported cases. Although its rarity, we consider that pulmonary nodular lymphoid hyperplasia should be considered in the differential diagnosis of lung nodules or masses among Sjögren’s syndrome patients.