Temporal and extratemporal atrophic manifestation of temporal lobe epilepsy using voxel-based morphometry and corticometry: clinical application in lateralization of epileptogenic zone

• Published in: Neurological sciences Vol. 42; no. 8; pp. 3305 - 3325
• Main Authors: Jber, Majdi, Habibabadi, Jafar Mehvari, Sharifpour, Roya, Marzbani, Hengameh, Hassanpour, Masoud, Seyfi, Milad, Mobarakeh, Neda Mohammadi, Keihani, Ahmedreza, Hashemi-Fesharaki, Seyed Sohrab, Ay, Mohammadreza, Nazem-Zadeh, Mohammad-Reza
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2021; Springer Nature B.V
• Subjects: Atrophy; Epilepsy; Globus pallidus; Hemispheric laterality; Hippocampus; Magnetic resonance imaging; Medicine; Medicine & Public Health; Morphometry; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Original Article; Patients; Psychiatry; Substantia grisea; Temporal lobe; Thalamus; Thinning; T1-weighted MRI; Cortical thickness; Volumetric assessment; Voxel-based morphometry; Temporal lobe epilepsy; Hippocampus; Subcortical structures; Lateralization
• ISSN: 1590-1874; 1590-3478
• DOI: 10.1007/s10072-020-05003-2

Background Advances in MRI acquisition and data processing have become important for revealing brain structural changes. Previous studies have reported widespread structural brain abnormalities and cortical thinning in patients with temporal lobe epilepsy (TLE), as the most common form of focal epilepsy. Methods In this research, healthy control cases ( n  = 20) and patients with left TLE ( n  = 19) and right TLE ( n  = 14) were recruited, all underwent 3.0 T MRI with magnetization-prepared rapid gradient echo sequence to acquire T1-weighted images. Morphometric alterations in gray matter were identified using voxel-based morphometry (VBM). Volumetric alterations in subcortical structures and cortical thinning were also determined. Results Patients with left TLE demonstrated more prevailing and widespread changes in subcortical volumes and cortical thickness than right TLE, mainly in the left hemisphere, compared to the healthy group. Both VBM analysis and subcortical volumetry detected significant hippocampal atrophy in ipsilateral compared to contralateral side in TLE group. In addition to hippocampus, subcortical volumetry found the thalamus and pallidum bilaterally vulnerable to the TLE. Furthermore, the TLE patients underwent cortical thinning beyond the temporal lobe, affecting gray matter cortices in frontal, parietal, and occipital lobes in the majority of patients, more prevalently for left TLE cases. Exploiting volume changes in individual patients in the hippocampus alone led to 63.6% sensitivity and 100% specificity for lateralization of TLE. Conclusion Alteration of gray matter volumes in subcortical regions and neocortical temporal structures and also cortical gray matter thickness were evidenced as common effects of epileptogenicity, as manifested by the majority of cases in this study.