Assessment of BNP and NT-proBNP in emergency department patients presenting with suspected acute coronary syndromes

• Published in: Clinical biochemistry Vol. 39; no. 1; pp. 11 - 18
• Main Authors: Cameron, Scott J., Green, Gary B., White, C. Nicole, Laterza, Omar F., Clarke, William, Kim, Hong, Sokoll, Lori J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 2006
• Subjects: Acute Disease; Adult; Aged; Aged, 80 and over; BNP; Chest pain; Coronary Disease - blood; Correlation; Emergency department; Emergency Service, Hospital; Female; Humans; Male; Middle Aged; Natriuretic Peptide, Brain - blood; NT-proBNP; Peptide Fragments - blood; Syndrome; Correlation; NT-proBNP; Emergency department; BNP; Chest pain
• ISSN: 0009-9120; 1873-2933
• DOI: 10.1016/j.clinbiochem.2005.10.011

The relationship between BNP and NT-proBNP among physiologically and clinically relevant demographic subgroups has never been clarified in the context of the emergency department (ED). A blood sample taken from patients presenting to the E.D. with suspected acute coronary syndromes (ACS) was analyzed for BNP and NT-proBNP, and correlation between them was examined as an entire group then as subgroups according to gender, ethnicity, age, and comorbidity variables. BNP and NT-proBNP correlate well (0.89, P < 0.0001) in a population of 420 patients and in patient subgroups with a history of various etiologies, including vascular disorders. In general, BNP and NT-proBNP correlate very well in patients with suspected ACS and may aid in the risk stratification process in emergency departments.