Surgical Outcomes for Hepatocellular Carcinoma in Patients with Child–Pugh Class B: a Retrospective Multicenter Study

• Published in: Journal of gastrointestinal surgery Vol. 27; no. 2; pp. 283 - 295
• Main Authors: Tanaka, Shogo, Noda, Takehiro, Komeda, Koji, Kosaka, Hisashi, Iida, Hiroya, Ueno, Masaki, Hokuto, Daisuke, Ikoma, Hisashi, Nakai, Takuya, Kabata, Daijiro, Shinkawa, Hiroji, Kobayashi, Shogo, Hirokawa, Fumitoshi, Mori, Haruki, Hayami, Shinya, Morimura, Ryo, Matsumoto, Masataka, Ishizawa, Takeaki, Kubo, Shoji, Kaibori, Masaki
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2023; Springer Nature B.V
• Subjects: alpha-Fetoproteins; Ascites; Carcinoma, Hepatocellular - pathology; Disease-Free Survival; Gastroenterology; Gastrointestinal surgery; Hospital Mortality; Hospitals; Humans; Liver cancer; Liver Neoplasms - pathology; Medicine; Medicine & Public Health; Multivariate analysis; Original Article; Postoperative Complications - epidemiology; Postoperative Complications - etiology; Prognosis; Respiratory failure; Retrospective Studies; Risk factors; Surgery; Surgical outcomes; Hepatocellular carcinoma; Operation time; AFP; ALBI grade
• ISSN: 1091-255X; 1873-4626
• DOI: 10.1007/s11605-022-05549-w

Backgrounds Liver resection for hepatocellular carcinoma (HCC) in patients with Child–Pugh class (CPC) B increases the incidence of postoperative complication and in-hospital death and decreases the disease-free survival (DFS) and overall survival (OS) compared with those with CPC A. Conversely, some selected patients possibly gained benefits for liver resection. Methods Clinical records of 114 patients with CPC B who underwent liver resection for HCC were retrospectively reviewed. The risk of postoperative complications (Clavien–Dindo classification grade of ≥ II), postoperative recurrence, and death was analyzed. Results Postoperative complications occurred in 36 patients (31.6%), and 2 died within 90 days postoperatively due to the liver and respiratory failure, respectively. Multivariate analysis indicated that albumin-bilirubin (ALB) grade III and extended operation time were found as independent risk factors for postoperative complications. The DFS and OS rates at 3/5 years after liver resection were 30.8%/25.3% and 68.4%/48.9%, respectively. Multivariate analysis indicated that the extended blood loss, high α-fetoprotein (AFP) level (≥ 200 ng/mL), and Barcelona Clinic Liver Cancer stage C were found to be independent risk factors for postoperative recurrence. The high AFP level was also an independent prognostic factor for OS. Patients with high AFP levels had postoperative recurrence within 2 years and a higher number of extrahepatic recurrences than those with low AFP levels (< 200 ng/mL). Conclusion For patients with HCC with CPC B who were scheduled for liver resection, ALBI grade III and high AFP level should be considered as unfavorable outcomes after liver resection.