Assessment of lacrimal gland involvement in primary Sjögren’s syndrome using gray-scale ultrasonography and shear wave elastography

• Published in: European radiology Vol. 33; no. 12; pp. 9368 - 9377
• Main Authors: Özer, Halil, Yılmaz, Sema, Bozkurt, Banu, Tezcan, Dilek, Yazol, Merve, Hakbilen, Selda, Topaloğlu, Ömer Faruk, Durmaz, Mehmet Sedat
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2023; Springer Nature B.V
• Subjects: Biopsy; Correlation; Diagnostic Radiology; Diagnostic systems; Elasticity; Exocrine glands; Eye examinations; Gray scale; Imaging; Internal Medicine; Interventional Radiology; Lacrimal gland and Nasolacrimal duct; Medicine; Medicine & Public Health; Neuroradiology; Radiology; Salivary gland; Salivary glands; Sensitivity; Shear; Sjogren's syndrome; Ultrasonic imaging; Ultrasound; Sjogren’s syndrome; Lacrimal gland; Sonoelastography; Ultrasonography
• ISSN: 1432-1084; 0938-7994; 1432-1084
• DOI: 10.1007/s00330-023-09943-z

Objectives The aim of this study was to assess lacrimal gland involvement in primary Sjögren’s syndrome (pSS) using lacrimal gland gray-scale ultrasound (LGUS) and two-dimensional shear wave elastography (2D-SWE). Methods Eighty-five pSS patients with a mean age of 51.16 ± 10.61 years and 84 sex- and age-matched healthy subjects with a mean age of 50.94 ± 11.05 years were included in the study. Lacrimal gland parenchymal findings and 2D-SWE values were compared between the two groups and the correlations of LGUS parameters with clinical findings, dry eye tests, and minor salivary gland biopsy (MSGB) were further investigated. Results LGUS parenchymal grade was 0 in 14 (16.5%), 1 in 45 (52.9%), 2 in 23 (27.1%), and 3 in 3 patients (3.5%) in the pSS group, while in the control group, parenchymal grades were 0 (57.1%) and 1 (42.9%). The mean 2D-SWE value of pSS patients was significantly higher than the control group ( p  < 0.05) and increased parallel with lacrimal parenchymal grade. The elasticity modulus had a high diagnostic performance in detecting lacrimal gland involvement in pSS patients (AUC 0.901, sensitivity 70.6%, specificity 97.6%), while the diagnostic performance of LGUS was much lower (AUC 0.769, sensitivity 83.5%, specificity 57.1%). LGUS and 2D-SWE values were found to be correlated with dry eye tests and MSGB results ( p  < 0.05). Conclusions LGUS and 2D-SWE are both useful for assessing the lacrimal gland involvement in pSS patients; however, 2D-SWE has a better diagnostic performance than LGUS and found to be correlated with dry eye tests. Clinical relevance statement Lacrimal gland US and two-dimensional shear wave elastography (2D-SWE) are imaging modalities that can be used to demonstrate parenchymal involvement of the lacrimal gland in primary Sjögren’s syndrome (pSS). Key Points • Gray-scale US and two-dimensional shear wave elastography (2D-SWE) have been widely used in the recent decade to assess gland involvement in patients with primary Sjögren’s syndrome (pSS) . • The elasticity modulus had a high diagnostic performance in detecting lacrimal gland involvement in primary Sjögren’s syndrome (pSS) patients . • Lacrimal gland US and two-dimensional shear wave elastography (2D-SWE) are both useful for assessing the lacrimal gland in primary Sjögren’s syndrome (pSS) patients; however, two-dimensional shear wave elastography (2D-SWE) has a better diagnostic performance than lacrimal gland ultrasound (LGUS) .