Time- and frequency-resolved covariance analysis for detection and characterization of seizures from intracraneal EEG recordings

• Published in: Biological cybernetics Vol. 114; no. 4-5; pp. 461 - 471
• Main Authors: Maidana Capitán, Melisa, Cámpora, Nuria, Sigvard, Claudio Sebastián, Kochen, Silvia, Samengo, Inés
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2020; Springer Nature B.V
• Subjects: Algorithms; Analysis of covariance; Bioinformatics; Biomedical and Life Sciences; Biomedicine; Complex Systems; Computer Appl. in Life Sciences; Consciousness; Convulsions & seizures; Covariance; EEG; Electroencephalography; Epilepsy; Frequencies; Frequency analysis; Neurobiology; Neurosciences; Original Article; Patients; Principal components analysis; Seizures; Variance; Consciousness; EEG; Epilepsy; Principal component analysis
• ISSN: 0340-1200; 1432-0770; 1432-0770
• DOI: 10.1007/s00422-020-00840-y

The amount of power in different frequency bands of the electroencephalogram (EEG) carries information about the behavioral state of a subject. Hence, neurologists treating epileptic patients monitor the temporal evolution of the different bands. We propose a covariance-based method to detect and characterize epileptic seizures operating on the band-filtered EEG signal. The algorithm is unsupervised and performs a principal component analysis of intra-cranial EEG recordings, detecting transient fluctuations of the power in each frequency band. Its simplicity makes it suitable for online implementation. Good sampling of the non-ictal periods is required, while no demands are imposed on the amount of data during ictal activity. We tested the method with 32 seizures registered in 5 patients. The area below the resulting receiver-operating characteristic curves was 87% for the detection of seizures and 91% for the detection of recruited electrodes. To identify the behaviorally relevant correlates of the physiological signal, we identified transient changes in the variance of each band that were correlated with the degree of loss of consciousness, the latter assessed by the so-called Consciousness Seizure Scale, summarizing the performance of the subject in a number of behavioral tests requested during seizures. We concluded that those crisis with maximal impairment of consciousness tended to exhibit an increase in variance approximately 40 s after seizure onset, with predominant power in the theta and alpha bands and reduced delta and beta activity.