Relationship Between Markers of Chronic Inflammation and Copper Nutritional Status in Obese Women

• Published in: Biological trace element research Vol. 201; no. 7; pp. 3133 - 3143
• Main Authors: de Paiva Sousa, Mickael, Fontenelle, Larissa Cristina, de Sousa, Thayanne Gabryelle Visgueira, dos Santos, Loanne Rocha, Cruz, Kyria Jayanne Clímaco, da Cunha Soares, Tamires, Braz, Débora Cavalcante, de Castro e Sousa, João Marcelo, Henriques, Gilberto Simeone, Silva, Vladimir Costa, Costa, Carlos Henrique Nery, do Nascimento Marreiro, Dilina
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2023; Springer Nature B.V
• Subjects: Adipose tissue; Biochemistry; Biomedical and Life Sciences; Biotechnology; Copper; Cross-Sectional Studies; Cytokines; Erythrocytes; Eutrophication; Female; Homeostasis; Humans; Inductively coupled plasma; Inflammation; Inflammation - metabolism; Interleukin 10; Interleukin 12; Interleukin 6; Interleukin 8; Life Sciences; Necrosis; Nutrition; Nutritional Status; Obesity; Obesity - metabolism; Oncology; Optical emission spectroscopy; Serum; Spectrometry; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Women; Obesity; Inflammation; Nutritional Status; Copper
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-022-03407-z

Adipose tissue dysfunction causes the development of metabolic complications, such as low-grade chronic inflammation, which may to alter copper homeostasis in obese individuals. Thus, the objective of this study is to analyze the relationship between markers of chronic inflammation and copper nutritional status in obese women. Cross-sectional study involved women aged 20–50 years, divided into two groups: case (BMI > 35 kg/m 2 ) and control (18.5 > BMI > 24.9 kg/m 2 ). Plasma and erythrocyte copper concentrations were determined by inductively coupled plasma optical emission spectrometry (ICP-OES) method. Activity of superoxide dismutase (SOD) enzyme in the erythrocytes was determined with an automatic biochemical analyzer. Serum concentrations of interleukin (IL)-6, IL-8, IL-12, IL-10, and IL-1β and tumor necrosis factor-alpha (TNF-α) were determined by using flow cytometer. Serum IL-6 concentrations were 105% higher in the case group compared to eutrophic women. Plasma copper concentrations were 20.5% higher, and erythrocyte copper concentrations were 23.5% lower in patients with obesity. In addition, erythrocyte SOD activity was 20% lower in obese participants when compared to eutrophic women. Our study identified significant negative correlation between the cytokines TNF-α and IL-10 and the SOD activity in the case group, suggesting a possible influence of chronic inflammation on copper distribution in obese individuals.