Co-occurrence of Psychopathology Problems in At-Risk Adolescents
No known studies have investigated co-occurrence of psychopathology problems in adolescents with biologic and/or environmental susceptibility, including prenatal drug exposure. This study identified comorbidity patterns of psychopathology problems by utilizing data from urban, primarily African Amer...
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Published in | Journal of psychopathology and behavioral assessment Vol. 44; no. 4; pp. 1110 - 1125 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
01.12.2022
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | No known studies have investigated co-occurrence of psychopathology problems in adolescents with biologic and/or environmental susceptibility, including prenatal drug exposure. This study identified comorbidity patterns of psychopathology problems by utilizing data from urban, primarily African American, youth, majority of whom were at heightened risk for exposure to drugs in utero. The roles of Research Domain Criteria (RDoC)-informed behavioral constructs of the Negative Valence (irritability) and Social Process Systems (social disinhibition) as antecedents of the comorbidity patterns were further examined. Lastly, the predictive validity of the identified patterns was evaluated in relation to emerging adulthood outcomes. Participants were 358 urban adolescents, primarily African Americans, drawn from a 21-year prospective birth-cohort study of the effects of prenatal drug exposure. Psychopathology problems were assessed at age 15. Irritability and social disinhibition were self-reported at age 12. Emerging adulthood outcomes were measured at age 21. Latent class modeling indicated four patterns:
Normative
(57%),
substance-use
(SU; 24%),
mental-health-problems-without-substance-use
(MH; 11%), and
substance-use-and-other-mental-health-problems
(SUMH; 7%). Higher irritability increased the odds of developing the MH pattern, whereas higher social disinhibition increased the odds of developing the SU pattern. The odds of manifesting the SUMH pattern were higher for children with higher irritability. For children with higher social disinhibition, the odds of manifesting the SUMH pattern were higher at a trend level. Adolescent comorbidity patterns were differentially associated with problematic tobacco and marijuana use and clinically relevant mental health problems in emerging adulthood, and completion of high school education. Peri-pubertal identification of individual differences in irritability and social disinhibition may mitigate the emergence of adolescent psychopathology, which could influence emerging adulthood adjustment in this at-risk population. |
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Bibliography: | Authors’ contributions: Dr. June-Yung Kim conceptualized the paper, performed the statistical analyses, and wrote the initial and final draft. Dr. Sonia Minnes designed the study and provided input on the conceptualization of the paper and interpretation of the data. Dr. Meeyoung O. Min provided the input on the conceptualization of the paper, statistical analyses, and interpretation of the data. Dr. Ty A. Ridenour provided input on the interpretation of the data. All authors contributed to critical revision of the manuscript for important intellectual content and read and approved the final manuscript. |
ISSN: | 0882-2689 1573-3505 |
DOI: | 10.1007/s10862-022-09980-w |