Attempting to Increase the Effectiveness of the Antidepressant Trazodone Hydrochloride Drug Using π-Acceptors

• Published in: International journal of environmental research and public health Vol. 19; no. 18; p. 11281
• Main Authors: Alsanie, Walaa F, Alhomrani, Majid, Alamri, Abdulhakeem S, Alyami, Hussain, Shakya, Sonam, Habeeballah, Hamza, Alkhatabi, Heba A, Felimban, Raed I, Alamri, Abdulwahab, Alhabeeb, Abdulhameed Abdullah, Raafat, Bassem M, Refat, Moamen S, Gaber, Ahmed
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.09.2022; MDPI
• Subjects: Acetylcholine; Antidepressants; Antidepressive Agents - therapeutic use; Charge transfer; Depressive Disorder, Major - drug therapy; Dopamine; Dopamine - metabolism; Drugs; Energy value; Humans; Investigations; Ion pairs; Ligands; Liquid phases; Mental depression; Molecular docking; Molecular Docking Simulation; Molecular dynamics; Molecular modelling; Neurotransmitter Agents; Neurotransmitters; Norepinephrine; Proteins; Serotonin; Serotonin - metabolism; Serotonin receptors; Software; Solid phases; Trazodone - therapeutic use; trazodone HCl; molecular docking; depression; charge transfer complex; spectroscopic
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph191811281

Major depressive disorder is a prevalent mood illness that is mildly heritable. Cases with the highest familial risk had recurrence and onset at a young age. Trazodone hydrochloride is an antidepressant medicine that affects the chemical messengers in the brain known as neurotransmitters, which include acetylcholine, norepinephrine, dopamine, and serotonin. In the present research, in solid and liquid phases, the 1:1 charge-transfer complexes between trazodone hydrochloride (TZD) and six different π-acceptors were synthesized and investigated using different microscopic techniques. The relation of dative ion pairs [TZD+, A-], where A is the acceptor, was inferred via intermolecular charge-transfer complexes. Additionally, a molecular docking examination was utilized to compare the interactions of protein receptors (serotonin-6BQH) with the TZD alone or in combination with the six distinct acceptor charge-transfer complexes. To refine the docking results acquired from AutoDock Vina and to better examine the molecular mechanisms of receptor-ligand interactions, a 100 ns run of molecular dynamics simulation was used. All the results obtained in this study prove that the 2,6-dichloroquinone-4-chloroimide (DCQ)/TZD complex interacts with serotonin receptors more efficiently than reactant donor TZD only and that [(TZD)(DCQ)]-serotonin has the highest binding energy value of all π-acceptor complexes.