Associations between polysomnography measurements and postoperative adverse respiratory events in children with neuromuscular disease

• Published in: Journal of clinical sleep medicine Vol. 17; no. 4; pp. 757 - 765
• Main Authors: Fishman, Haley, Hamid, Jemila S, Barrowman, Nick, Momoli, Franco, Maclusky, Ian, Katz, Sherri Lynne
• Format: Journal Article
• Language: English
• Published: United States American Academy of Sleep Medicine 01.04.2021
• Subjects: Child; Humans; Neuromuscular Diseases; Polysomnography; Postoperative Complications; Retrospective Studies; Risk Factors; Scientific Investigations; Tonsillectomy; postoperative; neuromuscular disease; pulmonary; polysomnography; complications; pediatrics
• ISSN: 1550-9389; 1550-9397
• DOI: 10.5664/jcsm.9026

To determine if polysomnographic cardiorespiratory outcomes are associated with and could have the potential to predict the presence of postoperative adverse respiratory events in children with neuromuscular disease undergoing any surgical procedure. A retrospective cohort study was conducted at a tertiary pediatric institution. The study population included individuals with neuromuscular disease admitted for a surgical intervention under general anesthetic who had undergone a polysomnogram within 1 year before surgical intervention. Polysomnographic indices and postoperative adverse respiratory events were collected through chart review. Multivariable logistic regression was used to model postoperative adverse respiratory events, where PSG results were considered primary predictors. Postoperative adverse respiratory events occurred in 25/61 (41%) of individuals and consisted mainly of desaturations requiring intervention 33 (73%), airway obstruction 15 (33%), and atelectasis (22%). Results from the unadjusted and adjusted logistic regression models indicated that saturation nadir and bulbar dysfunction individually were independent risk factors for postoperative adverse respiratory events with the highest areas under the receiver operating characteristic curve. A multivariable prediction model using these 2 risk factors provided an area under the receiver operating characteristic curve of 0.74 (95% confidence interval, 0.65-0.83). Knowing that nocturnal oxygen saturation nadir and the presence of bulbar dysfunction are potential predictors of postoperative adverse respiratory events is useful for future counseling of families and surgical planning, in an effort to improve perioperative management and reduce adverse events.