NcRNAs and Cholangiocarcinoma

Cholangiocarcinoma (CCA) is the most common primary biliary malignancy with poor prognosis. Less understanding of its etiology and pathogenesis makes the diagnosis and therapy difficult. Recently, accumulating evidences have demonstrated that deregulated expression of non-coding RNAs (ncRNAs) is clo...

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Bibliographic Details
Published inJournal of Cancer Vol. 9; no. 1; pp. 100 - 107
Main Authors Wangyang, Zheng, Daolin, Ji, Yi, Xu, Zhenglong, Li, Lining, Huang, Yunfu, Cui, Xingming, Jiang
Format Journal Article
LanguageEnglish
Published Australia Ivyspring International Publisher 2018
Subjects
Review
Biomarkers
Non-noncoding RNAs
Circular RNAs
Cholangiocarcinoma
Therapeutic targets
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Summary:Cholangiocarcinoma (CCA) is the most common primary biliary malignancy with poor prognosis. Less understanding of its etiology and pathogenesis makes the diagnosis and therapy difficult. Recently, accumulating evidences have demonstrated that deregulated expression of non-coding RNAs (ncRNAs) is closely associated with the etiopathogenesis of CCA. NcRNAs which lack open reading frame are a heterogeneous class of transcribed RNA molecules, including microRNAs, long non-coding RNAs and circular RNAs. Several studies have shown ncRNAs dysregulation is a common central event occurring in CCA and has the potential of being therapy targets. Moreover, ncRNAs can be easily detected in cancer tissues and biofluids, representing valuable tools for diagnosis. In this review, we illustrate the role of ncRNA in the CCA and discuss their potential clinical value.
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Competing Interests: The authors have declared that no competing interest exists.
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.21785