Recent Development on Sensing Strategies for Small Molecules Detections

• Published in: Journal of fluorescence Vol. 34; no. 4; pp. 1493 - 1525
• Main Authors: Saleem, Muhammad, Hanif, Muhammad, Rafiq, Muhammad, Ali, Anser, Raza, Hussain, Kim, Song Ja, Lu, Changrui
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2024; Springer Nature B.V
• Subjects: Adenosine triphosphate; Analytical Chemistry; Biochemistry; Biological and Medical Physics; Biomarkers; Biomedical and Life Sciences; Biomedicine; Biophysics; Biosensing Techniques - methods; Biotechnology; Carbohydrates; Ethanol; Glutathione; Hydrazines; Hydrogen peroxide; Inorganic compounds; Literature reviews; Low molecular weights; Medical imaging; Methyl parathion; Monitoring; Nitrosamine; Optical properties; Pesticides; Phospholipids; Pollutants; Receptors; Review; Small Molecule Libraries - analysis; Small Molecule Libraries - chemistry; Telemedicine; Titration; VOCs; Volatile organic compounds; Organic Small Molecular Monitoring; Analytical Parameters; Chemodosimeter; Optical; Chemosensors; Electrochemical
• ISSN: 1053-0509; 1573-4994; 1573-4994
• DOI: 10.1007/s10895-023-03387-w

Sensors play a critical role in the detection and monitoring of various substances present in our environment, providing us with valuable information about the world around us. Within the field of sensor development, one area that holds particular importance is the detection of small molecules. Small molecules encompass a wide range of organic or inorganic compounds with low molecular weight, typically below 900 Daltons including gases, volatile organic compounds, solvents, pesticides, drugs, biomarkers, toxins, and pollutants. The accurate and efficient detection of these small molecules has attracted significant interest from the scientific community due to its relevance in diverse fields such as environmental pollutants monitoring, medical diagnostics, industrial optimization, healthcare remedies, food safety, ecosystems, and aquatic and terrestrial life preservation. To meet the demand for precise and efficient monitoring of small molecules, this summary aims to provide an overview of recent advancements in sensing and quantification strategies for various organic small molecules including Hydrazine, Glucose, Morpholine, Ethanol amine, Nitrosamine, Oxygen, Nitro-aromatics, Phospholipids, Carbohydrates, Antibiotics, Pesticides, Drugs, Adenosine Triphosphate, Aromatic Amine, Glutathione, Hydrogen Peroxide, Acetone, Methyl Parathion, and Thiophenol. The focus is on understanding the receptor sensing mechanism, along with the electrical, optical, and electrochemical response. Additionally, the variations in UV–visible spectral properties of the ligands upon treatment with the receptor, fluorescence and absorption titration analysis for limit of detection (LOD) determination, and bioimaging analysis are discussed wherever applicable. It is anticipated that the information gathered from this literature survey will be helpful for the perusal of innovation regarding sensing strategies.