The Rotterdam Study. Design update and major findings between 2020 and 2024

• Published in: European journal of epidemiology Vol. 39; no. 2; pp. 183 - 206
• Main Authors: Ikram, M. Arfan, Kieboom, Brenda C.T., Brouwer, Willem Pieter, Brusselle, Guy, Chaker, Layal, Ghanbari, Mohsen, Goedegebure, André, Ikram, M. Kamran, Kavousi, Maryam, de Knegt, Rob J., Luik, Annemarie I., van Meurs, Joyce, Pardo, Luba M., Rivadeneira, Fernando, van Rooij, Frank J.A., Vernooij, Meike W., Voortman, Trudy, Terzikhan, Natalie
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.02.2024; Springer Nature B.V
• Subjects: Adult; Aged; Automation; Cancer; Cardiology; Cardiovascular disease; Chronic illnesses; Chronic obstructive pulmonary disease; Cohort analysis; Cohort Studies; Cohort Update; Cross cutting; Diabetes; Epidemiology; Etiology; Health Personnel; Heart failure; Humans; Infectious Diseases; Internal medicine; Liver diseases; Medical records; Medicine; Medicine & Public Health; Middle age; Middle Aged; Multidisciplinary research; Netherlands - epidemiology; Older people; Oncology; Otolaryngology; Population; Population studies; Public Health; Pulmonology; Research facilities; Target recognition; Web portals; Netherlands; Dermatological diseases; Liver diseases; Endocrine diseases; Oncology; Psychiatric diseases; Responsible research; Epidemiologic methods; Ophthalmic diseases; Risk factors; Cancer and related diseases; Neurological diseases; Pharmacoepidemiology; Population imaging; Renal diseases; Genetic and molecular epidemiology; Otolaryngological diseases; Cohort study; Respiratory diseases; Biomarkers; Cardiovascular diseases; Nutrition and lifestyle epidemiology
• ISSN: 0393-2990; 1573-7284
• DOI: 10.1007/s10654-023-01094-1

The Rotterdam Study is a population-based cohort study, started in 1990 in the district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the prevalence and incidence, unravel the etiology, and identify targets for prediction, prevention or intervention of multifactorial diseases in mid-life and elderly. The study currently includes 17,931 participants (overall response rate 65%), aged 40 years and over, who are examined in-person every 3 to 5 years in a dedicated research facility, and who are followed-up continuously through automated linkage with health care providers, both regionally and nationally. Research within the Rotterdam Study is carried out along two axes. First, research lines are oriented around diseases and clinical conditions, which are reflective of medical specializations. Second, cross-cutting research lines transverse these clinical demarcations allowing for inter- and multidisciplinary research. These research lines generally reflect subdomains within epidemiology. This paper describes recent methodological updates and main findings from each of these research lines. Also, future perspective for coming years highlighted.