Expanding the applications of photodynamic therapy—tooth bleaching
Objectives The current tooth bleaching materials are associated with adverse effect. Photodynamic method based on a novel photosensitizer alone, without combining with peroxides, is evaluated for tooth bleaching application. Materials and methods Teeth samples were randomly divided into 3 groups wit...
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Published in | Clinical oral investigations Vol. 26; no. 2; pp. 2175 - 2186 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.02.2022
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Objectives
The current tooth bleaching materials are associated with adverse effect. Photodynamic method based on a novel photosensitizer alone, without combining with peroxides, is evaluated for tooth bleaching application.
Materials and methods
Teeth samples were randomly divided into 3 groups with different treatment schemes, including negative control group (group A, physiological saline), experimental group (group B, ZnPc(Lys)
5
), and the positive control group (group C, hydrogen peroxide). Tooth color, surface microhardness, and roughness were determined at baseline, right after the first and second phase of bleaching, as well as 1 week and 1 month post-bleaching. Four samples in each group was randomly selected to evaluate the changes in surface morphology using the scanning electron microscope.
Results
The color change values (ΔE) in group B (7.10 ± 1.03) and C (12.22 ± 2.35) were significantly higher than that in group A (0.93 ± 0.30,
P
< 0.05). Additionally, surface microhardness and roughness were significantly affected in group C, but not in the group A and B. Furthermore, the scanning electron microscope images showed no adverse effect of enamel in the group A and B while the group C demonstrated corrosive changes.
Conclusions
ZnPc(Lys)
5
had a satisfactory bleaching effect and is promising to be a new type of tooth bleaching agent.
Clinical relevance
The current tooth bleaching materials give a satisfactory clinical outcome and long-term stability, but associated with some adverse reactions. Photosenstizer ZnPc(Lys)
5
eliminated the main side effects observed in hydrogen peroxide-based agents on the enamel, and also had a satisfactory bleaching effect and provide a novel selective bleaching scheme for clinical use. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-News-3 content type line 23 |
ISSN: | 1432-6981 1436-3771 |
DOI: | 10.1007/s00784-021-04199-7 |