Purification and characterization of anti-phytopathogenic fungi angucyclinone from soil-derived Streptomyces cellulosae
Actinomycete strain YIM PH20352, isolated from the rhizosphere soil sample of Panax notoginseng collected in WenShang, Yunnan Province, China, exhibited antifungal activity against some phytopathogenic fungi. The structures of bioactive molecules, isolated from the ethyl acetate extract of the ferme...
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Published in | Folia microbiologica Vol. 67; no. 3; pp. 517 - 522 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Dordrecht
Springer Netherlands
01.06.2022
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Actinomycete strain YIM PH20352, isolated from the rhizosphere soil sample of
Panax notoginseng
collected in WenShang, Yunnan Province, China, exhibited antifungal activity against some phytopathogenic fungi. The structures of bioactive molecules, isolated from the ethyl acetate extract of the fermentation broth of the strain, were identified as rabelomycin (1) and dehydrorabelomycin (2) based on extensive spectroscopic analyses. Compound 1 exhibited antifungal activity against four tested root-rot pathogens of the
Panax notoginseng
including
Plectosphaerella cucumerina
,
Alternaria panax
,
Fusarium oxysporum
, and
Fusarium solani
with the MIC values at 32, 64, 128, and 128 μg/mL, respectively. Compound 2 exhibited antifungal activity against
F. oxysporum
,
P. cucumerina
,
F. solani
, and
A. panax
with the MIC values at 64, 64, 128, and 128 μg/mL, respectively. Based on the phylogenetic analyses, the closest phylogenetic relative of strain YIM PH20352 is
Streptomyces cellulosae
NBRC 13027
T
(AB184265) (99.88%), so strain YIM PH20352 was identified as
Streptomyces cellulosae
. To the best of our knowledge, this is the first report of rabelomycin and rabelomycin-type antibiotics from
Streptomyces cellulosae
and their antifungal activity against root-rot pathogens of the
Panax notoginseng
. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0015-5632 1874-9356 |
DOI: | 10.1007/s12223-022-00957-6 |