Xenogeneic collagen matrix vs. connective tissue graft for the treatment of multiple gingival recession: a systematic review and meta-analysis

• Published in: Odontology Vol. 112; no. 2; pp. 317 - 340
• Main Authors: Zegarra-Caceres, Lorena, Orellano-Merluzzi, Ariana, Muniz, Francisco Wilker Mustafa Gomes, de Souza, Sérgio Luis Scombatti, Faveri, Marcelo, Meza-Mauricio, Jonathan
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.04.2024; Springer Nature B.V
• Subjects: Clinical trials; Collagen; Collagen - therapeutic use; Connective tissue; Connective Tissue - transplantation; Connective tissues; Dentistry; Gingiva; Gingival Recession - surgery; Graft-versus-host reaction; Heterografts - transplantation; Humans; Medicine; Meta-analysis; Oral and Maxillofacial Surgery; Randomized Controlled Trials as Topic; Review Article; Skin & tissue grafts; Statistical analysis; Systematic review; Gingival recessions; Acellular dermis; Connective tissue graft; Coronally advanced flap
• ISSN: 1618-1247; 1618-1255; 1618-1255
• DOI: 10.1007/s10266-023-00863-4

The aim of this systematic review (SR) compared the effect of xenogeneic collagen matrix (XCM) vs. connective tissue graft (CTG) for the treatment of multiple gingival recession (MGR) Miller Class I and II or Cairo type I. Five databases were searched up to August 2022 for randomized clinical trials (RCTs) comparing the clinical effects of XCM vs. CTG in the treatment of MGR. The random effects model of mean differences was used to determine reduction of gingival recession (GR), gain in keratinized tissue width (KTW), gain in gingival thickness (GT) and gain in clinical attachment level (CAL). The risk ratio was used to complete root coverage (CRC) at 6 and 12 months. 10 RCTs, representing 1095 and 649 GR at 6 and 12 months, respectively, were included in this SR. The meta-analysis showed no statistically significant difference in GR reduction, KTW gain GT gain or CAL gain between groups at 6 months. However, at 12 months of follow-up, differences favoring the control group were observed ( p  < 0.05). CRC was significantly higher in the CTG group at 6 and 12 months. Regarding dentine hypersensitivity (DH), no statistically significant differences were found between groups at 6 and 12 months of follow-up ( p  < 0.05). At 12 months, CTG showed significantly superior clinical results in the treatment of MGR: however, this difference was not observed in the decrease of DH.