Efficacy of a Glass Membrane Emulsification Device to Form Mixture of Cisplatin Powder with Lipiodol on Transarterial Therapy for Hepatocellular Carcinoma

• Published in: Cardiovascular and interventional radiology Vol. 44; no. 5; pp. 766 - 773
• Main Authors: Tanaka, Toshihiro, Iwamoto, Hideki, Fujihara, Mitsuteru, Nishiofuku, Hideyuki, Masada, Tetsuya, Suzuki, Hiroyuki, Koga, Hironori, Torimura, Takuji, Kichikawa, Kimihiko
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2021; Springer Nature B.V
• Subjects: Cardiology; Chemotherapy; Cisplatin; Cocks; Emulsification; Emulsions; Hepatocellular carcinoma; Imaging; Interventional Oncology; Laboratory Investigation; Liver cancer; Medicine; Medicine & Public Health; Membranes; Nuclear Medicine; Oil; Physiochemistry; Powder; Radiology; Ultrasound; Arterial embolization; Hepatocellular carcinoma; Lipiodol; Emulsion; Cisplatin
• ISSN: 0174-1551; 1432-086X
• DOI: 10.1007/s00270-020-02757-2

Purpose To examine physiochemical characteristics and drug release properties of cisplatin powder and lipiodol mixtures formed by a glass membrane emulsification device compared with a 3-way stopcock. Materials and Methods Seven different types of mixtures were evaluated: cisplatin powder and lipiodol directly mixed (suspension), complete cisplatin solution and lipiodol mixed by a 3-way stopcock or the device (emulsion), incomplete cisplatin solution and lipiodol mixed by a 3-way stopcock or the device (solid-in-water emulsion), and contrast material and cisplatin suspension mixed by a 3-way stopcock or the device (solid-in-oil emulsion). Result The percentages of water-in-oil were 98.08 ± 0.27% in the emulsion formed by the device, while 70.3 ± 4.63% in the emulsion formed by a 3-way stopcock ( P  = 0.037). Solid-in-water and solid-in-oil emulsions formed by the device showed 98.09 ± 0.38% and 98.70 ± 0.40% of water-in-oil, respectively, whereas both solid-in-water and solid-in-oil emulsions formed by a 3-way stopcock showed 0.00%. Homogenous droplet sizes were shown by using the device. The half release times of cisplatin in the emulsions formed by the device were 197 ± 19, 244 ± 24 and 478 ± 52 min, respectively, which were significantly longer than the emulsion formed by a 3-way stopcock of 8 ± 8 min ( P  = 0.046–0.050). Suspension showed the longest release time; however, the viscosity was lowest. Conclusion The glass membrane emulsification device formed almost 100% water-in-oil, whereas 3-way stopcock produced 100% oil-in-water when incomplete solution or suspension was mixed. Slower cisplatin release was shown in the emulsions formed by the device.