Velocity-pressure loops can estimate intrinsic and pharmacologically induced changes in cardiac afterload during non-cardiac surgery. An observational study

• Published in: Journal of clinical monitoring and computing Vol. 36; no. 2; pp. 545 - 555
• Main Authors: Le Gall, Arthur, Gayat, Étienne, Joachim, Jona, Cohen, Samuel, Hong, Alex, Matéo, Joaquim, Buxin, Cédric, Millasseau, Sandrine, Mebazaa, Alexandre, Vallée, Fabrice
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.04.2022; Springer Nature B.V
• Subjects: Age; Anesthesiology; Aorta; Cardiac output; Critical Care Medicine; Flow velocity; Health Sciences; Hemodynamics; Hypotension; Intensive; Medicine; Medicine & Public Health; Noradrenaline; Observational studies; Original Research; Pharmacology; Statistics for Life Sciences; Stiffness; Surgery; Vasoconstriction; Cardiac morbidity; Preoperative factors; Monitored anesthesia care; Ageing; Requirements; Cardiovascular physiology
• ISSN: 1387-1307; 1573-2614
• DOI: 10.1007/s10877-021-00686-0

Purpose Continuous measurement of aortic pressure and aortic flow velocity signals in the operating theatre allows us to draw velocity-pressure (Vel-Pre) loops. The global afterload angle (GALA), derived from the Vel-Pre loops, has been linked to cardiac afterload indicators. As age is the major determinant of constitutive arterial stiffness, we aimed to describe (1) the evolution of the GALA according to age in a large cohort of anesthetized patients and (2) GALA variations induced by haemodynamic interventions. Methods We included patients for whom continuous monitoring of arterial pressure and cardiac output were indicated. Fluid challenges or vasopressors were administered to treat intra-operative hypotension. The primary endpoint was the comparison of the GALA values between young and old patients. The secondary endpoint was the difference in the GALA values before and after haemodynamic interventions. Results We included 133 anaesthetized patients: 66 old and 67 young patients. At baseline, the GALA was higher in the old patients than in young patients (38 ± 6 vs. 25 ± 4 degrees; p < 0.001). The GALA was positively associated with age (p < 0.001), but the mean arterial pressure (MAP) and cardiac output were not. The GALA did not change after volume expansion, regardless of the fluid response, but it did increase after vasopressor administration. Furthermore, while a vasopressor bolus led to a similar increase in MAP, phenylephrine induced a more substantial increase in the GALA than noradrenaline (+ 12 ± 5° vs. + 8 ± 5°; p = 0.01). Conclusion In non-cardiac surgery, the GALA seems to be associated with both intrinsic rigidity (reflected by age) and pharmacologically induced vasoconstriction changes (by vasopressors). In addition, the GALA can discriminate the differential effects of phenylephrine and noradrenaline. These results should be confirmed in a prospective, ideally randomized, trial.