Collateral Blood Flow and Ischemic Core Growth

• Published in: Translational stroke research Vol. 14; no. 1; pp. 13 - 21
• Main Authors: Seifert, Kimberly, Heit, Jeremy J.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2023; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Brain; Brain Ischemia - diagnostic imaging; Brain Ischemia - therapy; Cardiology; Collateral Circulation - physiology; Endovascular Procedures - methods; Humans; Ischemia; Ischemic Stroke; Magnetic resonance imaging; Neurology; Neurosciences; Neurosurgery; Patients; Review Article; Stroke; Stroke - diagnostic imaging; Stroke - therapy; Thrombectomy; Treatment Outcome; Vascular Surgery; Veins & arteries; Stroke; Growth; Perfusion; Ischemic core; Collaterals
• ISSN: 1868-4483; 1868-601X
• DOI: 10.1007/s12975-022-01051-2

Treatment of a large vessel occlusion in the acute ischemic stroke setting focuses on vessel recanalization, and endovascular thrombectomy results in favorable outcomes in appropriate candidates. Expeditious treatment is imperative, but patients often present to institutions that do not have neurointerventional surgeons and need to be transferred to a comprehensive stroke center. These treatment delays are common, and it is important to identify factors that mitigate the progression of the ischemic core in order to maximize the preservation of salvageable brain tissue. Collateral blood flow is the strongest factor known to influence ischemic core growth, which includes the input arterial vessels, tissue-level vessels, and venous outflow. Collateral blood flow at these different levels may be imaged by specific imaging techniques that may also predict ischemic core growth during treatment delays and help identify patients who would benefit from transfer and endovascular therapy, as well as identify those patients in whom transfer may be futile. Here we review collateral blood flow and its relationship to ischemic core growth in stroke patients.