Breathing modulates gamma synchronization across species

• Published in: Pflügers Archiv Vol. 475; no. 1; pp. 49 - 63
• Main Authors: González, Joaquín, Cavelli, Matias, Mondino, Alejandra, Castro-Zaballa, Santiago, Brankačk, Jurij, Draguhn, Andreas, Torterolo, Pablo, Tort, Adriano B. L.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 2023; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Brain; Cats; Cell Biology; Chemical communication; Cortex (frontal); Cortex (olfactory); Electroencephalography; Gamma Rhythm; Human Physiology; Hypotheses; Mammals; Mice; Molecular Medicine; Neurosciences; Olfactory Bulb; Original Article; Oscillations; Rats; Receptors; Respiration; Sleep; Sleep and wakefulness; Synchronization; Cross-frequency coupling; Gamma oscillations; Respiration; Sleep–wake cycle; EEG; Brain rhythms
• ISSN: 0031-6768; 1432-2013
• DOI: 10.1007/s00424-022-02753-0

Nasal respiration influences brain dynamics by phase-entraining neural oscillations at the same frequency as the breathing rate and by phase-modulating the activity of faster gamma rhythms. Despite being widely reported, we still do not understand the functional roles of respiration-entrained oscillations. A common hypothesis is that these rhythms aid long-range communication and provide a privileged window for synchronization. Here we tested this hypothesis by analyzing electrocorticographic (ECoG) recordings in mice, rats, and cats during the different sleep–wake states. We found that the respiration phase modulates the amplitude of cortical gamma oscillations in the three species, although the modulated gamma frequency bands differed with faster oscillations (90–130 Hz) in mice, intermediate frequencies (60–100 Hz) in rats, and slower activity (30–60 Hz) in cats. In addition, our results also show that respiration modulates olfactory bulb-frontal cortex synchronization in the gamma range, in which each breathing cycle evokes (following a delay) a transient time window of increased gamma synchrony. Long-range gamma synchrony modulation occurs during quiet and active wake states but decreases during sleep. Thus, our results suggest that respiration-entrained brain rhythms orchestrate communication in awake mammals.