Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma

To investigate the possible association between functional variant Ala-9Val in the MnSOD gene and asthma in the case-control study comprising 626 Caucasian subjects. MnSOD genotypes were determined by PCR with subsequent restriction analysis by the BsaWI enzyme. Significant differences in allele fre...

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Bibliographic Details
Published inClinical biochemistry Vol. 39; no. 3; pp. 299 - 302
Main Authors Holla, Lydie Izakovicova, Kankova, Katerina, Vasku, Anna
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.2006
Subjects
Adult
Alleles
Asthma
Asthma - genetics
Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
MnSOD
Polymorphism
Polymorphism, Genetic - genetics
Superoxide dismutase
Superoxide Dismutase - genetics
Superoxide dismutase
MnSOD
Asthma
Polymorphism
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Summary:To investigate the possible association between functional variant Ala-9Val in the MnSOD gene and asthma in the case-control study comprising 626 Caucasian subjects. MnSOD genotypes were determined by PCR with subsequent restriction analysis by the BsaWI enzyme. Significant differences in allele frequencies between groups were not ascertained. Pursuant to these results, Ala-9Val polymorphism does not seem to be a significant predisposing factor for bronchial asthma in the Czech population.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2005.12.001