Structurally diverse polyketides and phenylspirodrimanes from the soft coral-associated fungus Stachybotrys chartarum SCSIO41201

• Published in: Journal of antibiotics Vol. 74; no. 3; pp. 190 - 198
• Main Authors: Yang, Bin, Long, Jieyi, Pang, Xiaoyan, Lin, Xiuping, Liao, Shengrong, Wang, Junfeng, Zhou, Xuefeng, Li, Yunqiu, Liu, Yonghong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2021; Springer Nature; Nature Publishing Group
• Subjects: 631/154/309/2144; 631/92/349; Antibiotics; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Biotechnology & Applied Microbiology; Crystallography; Cytotoxicity; Fungi; Immunology; Laboratories; Life Sciences; Life Sciences & Biomedicine; Medicinal Chemistry; Metabolites; Microbiology; Organic Chemistry; Pharmacology & Pharmacy; Science & Technology; Staphylococcus infections; SESQUITERPENES; METABOLITES; DITERPENOIDS; COLEOPHOMONE-B; SATRATOXIN-H; PROTON; INHIBITORS; A-H; SINULARIA; DERIVATIVES
• ISSN: 0021-8820; 1881-1469; 1881-1469
• DOI: 10.1038/s41429-020-00386-y

Four undescribed polyketide derivatives, named arthproliferins A–D ( 1 – 4 ), and one undescribed phenylspirodrimane derivative, named arthproliferin E ( 7 ), along with 11 known metabolites ( 5 , 6 , 8 – 16 ) were isolated from the soft coral-associated fungus Stachybotrys chartarum SCSIO41201. Their structures were determined through spectroscopic methods, X-ray crystallography, and ECD analysis. Compounds 1 and 3 – 15 were evaluated for their cytotoxic, and antibacterial activities. Among them, compounds 1 and 15 displayed moderate inhibitory activity against methicillin-resistant Staphylococcus aureus ATCC 29213 with an MIC value of 78 and 39 µg/mL, respectively. Furthermore, compound 15 displayed strong cytotoxic activities against the tested cell line with IC 50 values less than 39 nM.