Antibacterial and antimycobacterial activities of South African Salvia species and isolated compounds from S. chamelaeagnea

Extracts of 16 South African Salvia species commonly used in traditional medicine to treat various microbial infections were investigated for in vitro antibacterial and antimycobacterial activities using the micro-dilution and respiratory BACTEC method, respectively. The micro-organisms tested inclu...

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Published inSouth African journal of botany Vol. 73; no. 4; pp. 552 - 557
Main Authors Kamatou, G.P.P., Van Vuuren, S.F., Van Heerden, F.R., Seaman, T., Viljoen, A.M.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.11.2007
Subjects
7- O-Methylepirosmanol
Antibacterial activity
Antimycobacterial activity
Bacillus cereus
Carnosol
Escherichia coli
Klebsiella pneumoniae
Mycobacterium tuberculosis
Oleanolic acid
Salvia
Staphylococcus aureus
Ursolic acid
7- O-Methylepirosmanol
Antibacterial activity
Ursolic acid
Salvia
Antimycobacterial activity
Carnosol
Oleanolic acid
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Summary:Extracts of 16 South African Salvia species commonly used in traditional medicine to treat various microbial infections were investigated for in vitro antibacterial and antimycobacterial activities using the micro-dilution and respiratory BACTEC method, respectively. The micro-organisms tested include two Gram-positive ( Staphylococcus aureus and Bacillus cereus); two Gram-negative ( Escherichia coli and Klebsiella pneumoniae) bacterial strains and the common pathogen responsible for tuberculosis, Mycobacterium tuberculosis. Extracts of the majority of species exhibited moderate to good antibacterial activity with minimum inhibitory concentration (MIC) values ranging from 0.03 to 8.00 mg/ml. Promising activity was observed against M. tuberculosis (MIC ≤ 0.50 mg/ml) with S. radula, S. verbenaca and S. dolomitica displaying the most favourable activity (MIC: 0.10 mg/ml). The antibacterial bioassay-guided fractionation of S. chamelaeagnea resulted in the isolation of four compounds: carnosol, 7- O-methylepirosmanol, oleanolic acid and its isomer ursolic acid as the active principles against S. aureus. The in vitro antibacterial and antimycobacterial activities may support the use of Salvia species in traditional medicine to treat microbial infections.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0254-6299
1727-9321
DOI:10.1016/j.sajb.2007.05.001