Physiological fetal vascular shunts and failure to regress: what the radiologist needs to know

• Published in: Pediatric radiology Vol. 52; no. 7; pp. 1207 - 1223
• Main Authors: Leshen, Michael A., Devanagondi, Rajiv, Saul, David, Chaturvedi, Apeksha
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2022; Springer Nature B.V
• Subjects: Blood flow; Cardiovascular system; Congenital defects; Congenital diseases; Coronary vessels; Embryology; Fetuses; Flow distribution; Imaging; Medicine; Medicine & Public Health; Neuroradiology; Newborn babies; Nuclear Medicine; Oncology; Oxygenation; Pediatrics; Physiology; Radiology; Review; Shunts; Ultrasound; Radiography; Neonate; Patent ductus arteriosus; Shunt; Patent ductus venosus; Fetus; Patent foramen ovale; Fetal shunts; Ultrasound; Blood; Circulation
• ISSN: 0301-0449; 1432-1998
• DOI: 10.1007/s00247-022-05302-0

The fetal circulation is characterized by the presence of three physiological vascular shunts — the ductus arteriosus, the foramen ovale and the ductus venosus. Acting in concert, these shunts preferentially stream blood flow in a pattern that maximizes efficiency of blood oxygenation by the maternofetal unit. Shortly following the transition to extrauterine life, a quick and predetermined succession of events results in closure of these embryological structures with consequent establishment of postnatal vascular flow patterns. While this transition is often seamless, the physiological shunts of the fetus occasionally fail to regress. Such failure to regress can occur in isolation or in association with other congenital malformations. This failed regression challenges the circulatory physiology of the neonate and might have implications for the optimum functioning of several organ systems. When symptomatic, these shunts are treated. Interventions, when undertaken, might be medical, endovascular or surgical. The radiologist’s role continues to expand in the assessment of these shunts, in providing a roadmap for treatment and in prompt identification of treatment-related complications. This review is to familiarize radiologists with the embryology, pre- and post-treatment imaging appearances, and associated complications of persistent fetal vascular shunts.