Long non-coding RNAs in Colorectal Cancer: Progression and Future Directions

Identification of the colorectal adenoma-carcinoma sequence with its corresponding genetic and epigenetic alterations has significantly increased our knowledge of the etiopathogenesis of colorectal cancer (CRC). However, the molecular mechanisms of colorectal carcinogenesis and metastasis haven'...

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Published inJournal of Cancer Vol. 8; no. 16; pp. 3212 - 3225
Main Authors Yang, Yongzhi, Junjie, Peng, Sanjun, Cai, Ma, Yanlei
Format Journal Article
LanguageEnglish
Published Australia Ivyspring International Publisher 01.01.2017
Subjects
Research Paper
colorectal cancer (CRC)
tumorigenesis
biomarker
Long noncoding RNA (lncRNA)
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Summary:Identification of the colorectal adenoma-carcinoma sequence with its corresponding genetic and epigenetic alterations has significantly increased our knowledge of the etiopathogenesis of colorectal cancer (CRC). However, the molecular mechanisms of colorectal carcinogenesis and metastasis haven't been clearly elucidated. Long non-coding ribonucleic acids (lncRNAs) are key participants of gene regulations rather than "noises". Accumulative studies have implicated that the aberrant expressions of lncRNAs are tightly corelated to CRC screening, diagnosis, prognosis and therapeutic outcomes. Our review focuses on recent findings on the involvement of lncRNAs in CRC oncogenesis and the lncRNA-based clinical implications in patients with CRC.
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Competing Interests: The authors have declared that no competing interest exists.
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.19794