Natural products: potential therapeutic agents for atherosclerosis

Atherosclerosis (AS) is an invisible killer among cardiovascular diseases (CVD), which has seriously threatened the life of quality. The complex pathogenesis of AS involves multiple interrelated events and cell types, such as macrophages, endothelial cells, vascular smooth muscle cells and immune ce...

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Published inChinese journal of natural medicines Vol. 20; no. 11; pp. 830 - 845
Main Authors CHENG, Xiaobei, ZHAO, Caili, JIN, Zhiwei, HU, Jianping, ZHANG, Zhenzhen, ZHANG, Chao
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.11.2022
Subjects
Atherosclerosis
Cardiovascular diseases
Natural products
Pathogenesis
Target
Target
Cardiovascular diseases
Pathogenesis
Natural products
Atherosclerosis
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Summary:Atherosclerosis (AS) is an invisible killer among cardiovascular diseases (CVD), which has seriously threatened the life of quality. The complex pathogenesis of AS involves multiple interrelated events and cell types, such as macrophages, endothelial cells, vascular smooth muscle cells and immune cells. Currently, the efficacy of recommended statin treatment is not satisfactory. Natural products (NPs) have attracted increasing attention with regard to their broad structural diversity and biodiversity, which makes them a promising library in the demand for lead compounds with cardiovascular protective bio-activity. NPs can preclude the development of AS by regulating lipid metabolism, ameliorating inflammation, stabilizing plaques, and remodeling the gut microbiota, which lays a foundation for the application of NPs in clinical therapeutics.
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ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(22)60219-X