Development of biocompatible and biofilm-resistant silver-poly(methylmethacrylate) nanocomposites for stomatognathic rehabilitation

Recurrent prosthesis fracture and microbial contamination of the tissue bed or prosthetic materials remain the major clinical challenge for successful intraoral/faciomaxillary rehabilitation. Biocompatible and biofilm-resistant silver nanoparticle (AgNPs) based on poly(methyl methacrylate) was succe...

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Published inInternational journal of polymeric materials Vol. 69; no. 3; pp. 186 - 199
Main Authors Gopalakrishnan, Sandhya, Mathew T., Aby, Mozetič, Miran, V. P., Jayachandran, Jose, Jiya, Thomas, Sabu, Kalarikkal, Nandakumar
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 11.02.2020
Taylor & Francis Ltd
Subjects
AgNPs
anti bio-film property
antimicrobial analysis
Biocompatibility
Biofilms
Biomedical materials
constrained region
Infrared analysis
mechanical performance
Mechanical properties
Microorganisms
Modulus of elasticity
Nanocomposites
Nanoparticles
PMMA
Polymethyl methacrylate
Pressure molding
Prostheses
Rehabilitation
Silver
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Summary:Recurrent prosthesis fracture and microbial contamination of the tissue bed or prosthetic materials remain the major clinical challenge for successful intraoral/faciomaxillary rehabilitation. Biocompatible and biofilm-resistant silver nanoparticle (AgNPs) based on poly(methyl methacrylate) was successfully developed by a compression-molding technique. The AgNP-loaded PMMA were characterized using TEM, SEM, FT-IR and XRD analysis. The nanocomposites were found to be biocompatible and biofilm-resistant against Streptococcus mutans and Candida albicans. Mechanical performance of the nanocomposite was statistically analysed and modulus of elasticity was theoretically predicted using four models. The biomaterial developed in this study can be effectively used for stomatognathic rehabilitation.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2018.1552863