Ginkgo biloba Supplement Reverses Lead (II) Acetate–Induced Haematological Imbalances, Hepatic and Renal Dysfunctions in Male Wistar Rat

• Published in: Biological trace element research Vol. 200; no. 12; pp. 5134 - 5144
• Main Authors: Asiwe, Jerome Ndudi, Daubry, Tarela Melish Elias, Okon, Idara Asuquo, Akpotu, Ajirioghene Emamuzou, Adagbada, Ebunoluwa Oluwabusola, Eruotor, Harrison, Agbugba, Linda Chinyere, Buduburisi, Buduchim Rejoice
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2022; Springer Nature B.V
• Subjects: Acetates; Animals; Biochemistry; Biomedical and Life Sciences; Biotechnology; Dietary supplements; Enzymatic activity; Enzyme activity; Erythrocytes; Flavonoids; Fragility; Ginkgo biloba; Heavy metals; Hematology; Herbal medicine; Histology; Lead; Life Sciences; Liver; Natural products; Nutrition; Oncology; Oxidants; Oxidative stress; Oxidizing agents; Renal function; Rheological properties; Supplements; Toxicity; Haemorheology; Supplement; Oxidative stress; Haematology; Ginkgo biloba
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-022-03098-6

Lead is a heavy metal abundant in nature that causes haematological imbalances, and hepatic and renal dysfunction, and this imbalance has been linked to oxidative stress. Several reports have shown that natural products are implicated in ameliorating metal poisonings. Ginkgo biloba is a flavonoid-rich natural herbal supplement with several pharmacological properties. The present study investigated effect of Ginkgo biloba supplement (GBS) on lead-induced toxicity. Animals were given a lead dose of 25 mg/kg for 14 days orally and then given Ginkgo biloba supplements of 50 mg/kg and 100 mg/kg orally for 14 days. Animals given GBS had significantly improved haematological and rheological parameters. GBS showed a protective impact in terms of improved kidney and liver histology, anti-oxidant enzyme activity (CAT, SOD, GSH, and MDA), organ function indices, and a lower rate of erythrocyte osmotic fragility. Conclusively, Ginkgo biloba supplementation attenuated lead toxicity by normalization of haematological imbalances, and hepatic and renal dysfunction as well as maintaining erythrocyte membrane integrity.