Ginkgo biloba Supplement Reverses Lead (II) Acetate–Induced Haematological Imbalances, Hepatic and Renal Dysfunctions in Male Wistar Rat
Lead is a heavy metal abundant in nature that causes haematological imbalances, and hepatic and renal dysfunction, and this imbalance has been linked to oxidative stress. Several reports have shown that natural products are implicated in ameliorating metal poisonings. Ginkgo biloba is a flavonoid-ri...
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Published in | Biological trace element research Vol. 200; no. 12; pp. 5134 - 5144 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
01.12.2022
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Lead is a heavy metal abundant in nature that causes haematological imbalances, and hepatic and renal dysfunction, and this imbalance has been linked to oxidative stress. Several reports have shown that natural products are implicated in ameliorating metal poisonings.
Ginkgo biloba
is a flavonoid-rich natural herbal supplement with several pharmacological properties. The present study investigated effect of
Ginkgo biloba
supplement (GBS) on lead-induced toxicity. Animals were given a lead dose of 25 mg/kg for 14 days orally and then given
Ginkgo biloba
supplements of 50 mg/kg and 100 mg/kg orally for 14 days. Animals given GBS had significantly improved haematological and rheological parameters. GBS showed a protective impact in terms of improved kidney and liver histology, anti-oxidant enzyme activity (CAT, SOD, GSH, and MDA), organ function indices, and a lower rate of erythrocyte osmotic fragility. Conclusively,
Ginkgo biloba
supplementation attenuated lead toxicity by normalization of haematological imbalances, and hepatic and renal dysfunction as well as maintaining erythrocyte membrane integrity. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0163-4984 1559-0720 |
DOI: | 10.1007/s12011-022-03098-6 |