Holmium laser enucleation of the prostate versus thulium laser enucleation of the prostate for the treatment of large-volume prostates > 80 ml: 18-month follow-up results
Purpose To compare the perioperative and functional outcomes of holmium laser enucleation of the prostate (HoLEP) and thulium laser enucleation of the prostate (ThuLEP) for the treatment of large-volume benign prostatic hyperplasia (BPH) (> 80 ml). Methods A total of 116 consecutive patients with...
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Published in | World journal of urology Vol. 38; no. 6; pp. 1555 - 1562 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.06.2020
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Purpose
To compare the perioperative and functional outcomes of holmium laser enucleation of the prostate (HoLEP) and thulium laser enucleation of the prostate (ThuLEP) for the treatment of large-volume benign prostatic hyperplasia (BPH) (> 80 ml).
Methods
A total of 116 consecutive patients with BPH were randomized to be treated surgically with either HoLEP (
n
= 58) or ThuLEP (
n
= 58), following the classical three-lobe enucleation technique. Follow-up was assessed at 1, 3, 6, 12 and 18 months after surgery.
Results
At 18 months, the lower urinary tract symptom index was improved significantly in both groups compared with the baseline values. The operative time (78.4 ± 8.0 vs. 71.4 ± 6.4 min) and enucleation time (61.2 ± 5.4 vs. 56.4 ± 8.4 min) were significantly shorter for ThuLEP compared to HoLEP (both
p
< 0.001). There were no significant differences between the two groups regarding morcellation time, resected weight, hemoglobin decrease, catheter time and hospital stay (
p
> 0.05). The HoLEP and ThuLEP groups had equivalent International Prostate Symptom Scores (3 [3–3] vs. 3 [3–3],
p
= 0.776), quality of life (1 [1–2] vs. 2 [1–2],
p
= 0.809), Qmax (25.3 ± 4.8 ml/s vs. 24.7 ± 4.4 ml/s,
p
= 0.470), postvoid residual urine (PVR) (6.1 [2.6–20.8] vs. 7.7 [3.1–22.8] ml,
p
= 0.449) and PSA (0.84 ± 0.32 vs. 0.90 ± 0.34 ml,
p
= 0.309) at 18 months postoperatively.
Conclusion
Both HoLEP and ThuLEP relieve lower urinary tract symptoms in a comparable way with high efficacy and safety. ThuLEP was statistically superior to HoLEP in operation time and enucleation time, although the differences were clinically negligible. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 |
ISSN: | 0724-4983 1433-8726 |
DOI: | 10.1007/s00345-019-02945-x |