Outcome of thoracoscopic anatomical sublobar resection under 3-dimensional computed tomography simulation

• Published in: Surgical endoscopy Vol. 36; no. 4; pp. 2312 - 2320
• Main Authors: Hamada, Akira, Oizumi, Hiroyuki, Kato, Hirohisa, Suzuki, Jun, Nakahashi, Kenta, Takamori, Satoshi, Sho, Ri, Sadahiro, Mitsuaki
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2022; Springer Nature B.V
• Subjects: Abdominal Surgery; Carcinoma, Non-Small-Cell Lung - diagnostic imaging; Carcinoma, Non-Small-Cell Lung - surgery; Dissection; Endoscopy; Gastroenterology; Gynecology; Hepatology; Humans; Lung cancer; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - surgery; Medical prognosis; Medicine; Medicine & Public Health; Neoplasm Staging; Patients; Pneumonectomy - methods; Proctology; Pulmonary arteries; Retrospective Studies; Simulation; Surgery; Thoracic surgery; Tomography; Tomography, X-Ray Computed; Tumors; Veins & arteries; Segmentectomy/sub-segmentectomy/sub-sub-segmentectomy; Three-dimensional computed tomography (3DCT) simulation; Sublobar resection; Thoracoscopy/video-assisted thoracic surgery (VATS); Non-small cell lung cancer (NSCLC)
• ISSN: 0930-2794; 1432-2218
• DOI: 10.1007/s00464-021-08506-x

Background Previous studies have reported the feasibility and efficacy of thoracoscopic anatomical sublobar resection under three-dimensional computed tomography (3DCT) simulation; however, its long-term outcomes have not been clearly established in primary lung cancer. This study aimed to evaluate the long-term outcomes of this technique. Methods We retrospectively reviewed data from 112 consecutive patients with selected clinical stage IA non-small cell lung cancer (NSCLC) who underwent thoracoscopic anatomical sublobar resection from 2004 to 2014. This procedure was planned using preoperative 3DCT simulation to ensure sufficient surgical margins and enabled tailor-made surgery for each patient. Patients who had predominantly ground glass opacity lung cancers underwent anatomical sublobar resection as a curative-intent resection. Other patients who were high-risk candidates for lobectomy underwent anatomical sublobar resection as a compromised limited resection. Results Of the 112 cases, 82 had a curative-intent resection, while 30 had a compromised limited resection. Recurrence occurred in only 2 cases (1.8%), both of which were in the compromised limited group. A second primary lung cancer was observed in 5 cases (4.5%). Of the 5 patients, 4 underwent surgery for a second cancer and had no recurrence. The 5-year overall survival, lung cancer-specific overall survival, and recurrence-free survival rates were 92.5%, 100%, and 98.2%, respectively, for all cases; 97.6%, 100%, and 100%, respectively, in the curative-intent group; and 75.8%, 100% and 92.6%, respectively, in the compromised limited group. Conclusions Thoracoscopic anatomical sublobar resection under 3DCT simulation may be an acceptable alternative treatment in selected patients with NSCLC. Trial and clinical registry Clinical registration number: IRB No. 2020-98 (Dated: 2020.6.30).