Synthesis and characterization of camptothecin-rhamnolipid-layered double hydroxide nanohybrid and its controlled release property

• Published in: Journal of dispersion science and technology Vol. 41; no. 10; pp. 1496 - 1503
• Main Authors: Li, Yan, Mao, Xiao-Ming, Liang, Ya-Qin
• Format: Journal Article
• Language: English
• Published: Philadelphia Taylor & Francis 03.08.2020; Taylor & Francis Ltd
• Subjects: Camptothecin; Control stability; Controlled release; Diffusion rate; Drug delivery systems; Ethanol; Hydrophobicity; Hydroxides; Interlayers; layered double hydroxide (LDH) nanosheets; Morphology; Nanostructure; rhamnolipid; Rhamnolipids; secondary intercalation; Side effects; Thermal stability

Camptothecin (CPT) is a kind of hydrophobic anticancer drug. The clinical application of CPT is limited by its poor water solubility and serious side effects. In this work, layered double hydroxide (LDH) nanosheets were prepared in an aqueous synthetic route, and rhamnolipid (RL) anions were assembl...