Synthesis and characterization of camptothecin-rhamnolipid-layered double hydroxide nanohybrid and its controlled release property

• Published in: Journal of dispersion science and technology Vol. 41; no. 10; pp. 1496 - 1503
• Main Authors: Li, Yan, Mao, Xiao-Ming, Liang, Ya-Qin
• Format: Journal Article
• Language: English
• Published: Philadelphia Taylor & Francis 03.08.2020; Taylor & Francis Ltd
• Subjects: Camptothecin; Control stability; Controlled release; Diffusion rate; Drug delivery systems; Ethanol; Hydrophobicity; Hydroxides; Interlayers; layered double hydroxide (LDH) nanosheets; Morphology; Nanostructure; rhamnolipid; Rhamnolipids; secondary intercalation; Side effects; Thermal stability
• ISSN: 0193-2691; 1532-2351
• DOI: 10.1080/01932691.2019.1627880

Camptothecin (CPT) is a kind of hydrophobic anticancer drug. The clinical application of CPT is limited by its poor water solubility and serious side effects. In this work, layered double hydroxide (LDH) nanosheets were prepared in an aqueous synthetic route, and rhamnolipid (RL) anions were assembled with LDH nanosheets to form a RL-LDH nanohybrid. A CPT-intercalated RL-LDH (CPT-RL-LDH) nanohybrid was then prepared via hydrophobic interaction in a saturated ethanol solution of CPT. A possible morphology of CPT molecules in the hydrophobic interlayer region of RL-LDH was proposed according to the size of CPT molecule and the gallery height of the RL-LDH. The obtained CPT-RL-LDH nanohybrid showed high thermal stability and controlled release of CPT. The diffusion of CPT through CPT-RL-LDH particles was the rate-limiting step of CPT release. The drug-RL-LDH nanohybrids can be used as potential drug delivery materials.