Efficacy of high-intensity interval- or continuous aerobic-training on insulin resistance and muscle function in adults with metabolic syndrome: a clinical trial

• Published in: European journal of applied physiology Vol. 122; no. 2; pp. 331 - 344
• Main Authors: Gallo-Villegas, Jaime, Castro-Valencia, Leonardo A., Pérez, Laura, Restrepo, Daniel, Guerrero, Oscar, Cardona, Sergio, Sánchez, Yeliana L., Yepes-Calderón, Manuela, Valbuena, Luis H., Peña, Miguel, Milán, Andrés F., Trillos-Almanza, Maria C., Granados, Sergio, Aristizabal, Juan C., Estrada-Castrillón, Mauricio, Narvaez-Sanchez, Raúl, Osorio, Jorge, Aguirre-Acevedo, Daniel C., Calderón, Juan C.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2022; Springer Nature B.V
• Subjects: Adult; Biomarkers - blood; Biomedical and Life Sciences; Biomedicine; Blood glucose; Body composition; Body fat; Body mass index; Carnosine; Carnosine - blood; Clinical trials; Dual energy X-ray absorptiometry; Enzyme-linked immunosorbent assay; Female; Hemoglobin; High-Intensity Interval Training; Human Physiology; Humans; Insulin; Insulin resistance; Insulin Resistance - physiology; Magnetic resonance spectroscopy; Male; Metabolic syndrome; Metabolic Syndrome - physiopathology; Metabolic Syndrome - prevention & control; Middle Aged; Muscle contraction; Muscle Proteins - blood; NCT; NCT03087721; Occupational Medicine/Industrial Medicine; Original Article; Oxygen consumption; Skeletal muscle; Sports Medicine; Transcription Factors - blood; High-intensity interval training; Insulin resistance; Musclin; Metabolic syndrome; Skeletal muscle; Aerobic exercise
• ISSN: 1439-6319; 1439-6327
• DOI: 10.1007/s00421-021-04835-w

Purpose We carried out a randomized, clinical trial in adults of both sexes with metabolic syndrome (MS) to assess the efficacy of high-intensity, low-volume interval training (HIIT) compared to moderate-intensity continuous training (MICT) on insulin resistance (IR), muscle mass, muscle activation, and serum musclin. Methods Fasting glycemia, insulinemia, and glycated haemoglobin were determined by conventional methods, IR by Homeostatic model assessment (HOMA), lean mass by Dual-Energy X-ray Absorptiometry, muscle activation through carnosine by Proton Magnetic Resonance Spectroscopy, and musclin by Enzyme-Linked ImmunoSorbent Assay before and after a supervised, three-times/week, 12-week treadmill programme. HIIT ( n  = 29) consisted of six intervals with one-minute, high-intensity phases at 90% of peak oxygen consumption (VO 2peak ). MICT ( n  = 31) trained at 60% of VO 2peak for 30 min. Results Patients had a mean age of 50.8 ± 6.0 years, body mass index of 30.6 ± 4.0 kg/m 2 , and VO 2peak of 29.0 ± 6.3 mL.kg −1 .min −1 . Compared to MICT, HIIT was not superior at reducing Ln HOMA-IR (adjusted mean difference: 0.083 [95%CI − 0.092 to 0.257]), carnosine or musclin or at increasing thigh lean mass. HIIT increased carnosine by 0.66 mmol/kg.ww (95% CI 0.08–1.24) after intervention. Both interventions reduced IR, body fat percentage and increased total lean mass/height 2 and VO 2peak . Musclin showed a non-significant reduction with a small effect size after both interventions. Conclusion Compared to MICT, HIIT is not superior at reducing IR, carnosine or musclin or at increasing skeletal muscle mass in adults with MS. Both training types improved IR, muscle mass and body composition. NCT03087721, March 22nd, 2017. Trial registration number NCT03087721. Registered March 22nd, 2017.