Transcatheter Arterial Embolization with Bleomycin-Lipiodol of Hepatic Hemangiomas: Safety, Efficacy and Predictors of Response

• Published in: Cardiovascular and interventional radiology Vol. 47; no. 7; pp. 931 - 942
• Main Authors: Zhao, Dan, Xie, Lingli, Makamure, Joyman, Liu, Ziyi, Zhang, Lijie, Li, Qing, Zhang, Xin, Zhao, Yazhuo, Zheng, Chuansheng, Shi, Liangrong, Liang, Bin
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2024; Springer Nature B.V
• Subjects: Adult; Aged; Antibiotics, Antineoplastic - administration & dosage; Antibiotics, Antineoplastic - therapeutic use; Bleomycin; Bleomycin - therapeutic use; Cardiology; Chemoembolization, Therapeutic - methods; Clinical Investigation; Effectiveness; Embolisation (arterial); Embolization; Embolization, Therapeutic - methods; Ethiodized Oil - administration & dosage; Ethiodized Oil - therapeutic use; Female; Gelatin; Gelatin Sponge, Absorbable - therapeutic use; Hemangioma; Hemangioma - diagnostic imaging; Hemangioma - therapy; Humans; Imaging; Liver; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - therapy; Male; Medicine; Medicine & Public Health; Middle Aged; Nuclear Medicine; Radiology; Regression analysis; Retrospective Studies; Safety; Treatment Outcome; Tumor Burden; Tumors; Ultrasound; Liver hemangioma; Embolization; Bleomycin
• ISSN: 0174-1551; 1432-086X; 1432-086X
• DOI: 10.1007/s00270-024-03690-4

Purpose To evaluate the safety, efficacy and predictors of response of transcatheter arterial embolization (TAE) to treat hepatic hemangiomas (HHs). Materials and Methods A retrospective analysis was conducted of consecutive HH patients who received TAE with bleomycin-Lipiodol emulsion and gelatin sponge particles at three institutions from January 2014 to January 2021. TAE effectiveness was defined as more than 50% reduction of tumor volume. The effectiveness, safety, and CT changes of hemangiomas after TAE were assessed. Factors affecting TAE efficacy on tumor size were analyzed with logistic regression analysis. Results A total of 102 patients with 109 HHs were included. After treatment, both the tumor diameter and volume were significantly reduced from 8.5 ± 3.9 to 5.9 ± 3.8 cm ( P  < 0.001) and 412.6 ± 742.3 cm 3 to 102.0 ± 232.7 cm 3 ( P  < 0.001), respectively. TAE effectiveness was achieved in 80.7% (88/109) of hemangiomas, which was characterized by progressive reduction in tumor volume over time with Lipiodol retention. Atypical enhancement pattern (tiny enhancing dots in the hepatic arterial and portal venous phase) ( p  = 0.001) and central arterioportal shunt (APS) ( p  = 0.002) associated with the tumor were independent predictors of TAE ineffectiveness. Postembolization syndrome and transient increase in liver enzymes were common without severe complications and death. Conclusion TAE was safe and effective in reducing HH size. Lesion enhancement pattern and APS type were associated with TAE efficacy on tumor shrinkage. Level of Evidence Level 3, non-controlled retrospective cohort study. Graphical Abstract