Cocrystal Strategy toward Multifunctional 3D‐Printing Scaffolds Enables NIR‐Activated Photonic Osteosarcoma Hyperthermia and Enhanced Bone Defect Regeneration

• Published in: Advanced functional materials Vol. 30; no. 25
• Main Authors: Xiang, Huijing, Yang, Qianhao, Gao, Youshui, Zhu, Daoyu, Pan, Shanshan, Xu, Tianming, Chen, Yu
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.06.2020
• Subjects: 3D‐printing scaffolds; Ablation; Bioglass; biomaterials; Biomedical materials; Bone cancer; bone regeneration; cocrystal strategy; Differentiation (biology); Hyperthermia; Materials science; osteosarcoma; photonic hyperthermia; Photonics; Photothermal conversion; Regeneration (physiology); Scaffolds; Three dimensional printing; Tumors
• ISSN: 1616-301X; 1616-3028
• DOI: 10.1002/adfm.201909938

Malignant bone tumors are one of the major serious diseases in clinic. Inferior reconstruction of new bone and rapid propagation of residual tumor cells are the main challenges to surgical intervention. Herein, a bifunctional DTC@BG scaffold for near‐infrared (NIR)‐activated photonic thermal ablation of osteosarcoma and accelerated bone defect regeneration is engineered by in situ growth of NIR‐absorbing cocrystal (DTC) on the surface of a 3D‐printing bioactive glass (BG) scaffold. The prominent photothermal conversion performance and outstanding bone regeneration capability of DTC@BG scaffolds originate from the precise tailoring of the bandgap between the electron donors and acceptors of DTC and promote new bone growth performance of BG scaffolds. DTC@BG scaffolds not only significantly promote tumor cell ablation in vitro, but also effectively facilitate bone tumor suppression in vivo. In particular, DTC@BG scaffolds exhibit excellent capability in stimulating osteogenic differentiation and angiogenesis, and finally promote newborn bone formation in the bone defects. This research represents the first paradigm for ablating osteosarcoma and facilitating new bone formation through precise modulation of electron donors and acceptors in the cocrystal, which offers a new avenue to construct high‐efficiency therapeutic platforms based on cocrystal strategy for ablation of malignant bone tumor. Multifunctional 3D‐printing scaffolds are engineered for near‐infrared‐activated photonic thermal ablation of osteosarcoma and accelerated bone defect regeneration by precise modulation of electron donors and acceptors in the cocrystal. This research offers a new avenue to construct high‐efficiency therapeutic biomaterial platforms based on a cocrystal strategy for photonic osteosarcoma hyperthermia and enhanced bone defect regeneration.