Diabetes increases excretion of urinary malonaldehyde conjugates in rats

• Published in: Lipids Vol. 28; no. 7; pp. 663 - 666
• Main Authors: Gallaher, Daniel D., Csallany, A. Saari, Shoeman, Don W., Olson, Judith M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer‐Verlag 01.07.1993; Springer
• Subjects: aldehidos; aldehyde; aldehydes; Animals; Biological and medical sciences; diabete; diabetes; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - urine; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; experimentacion; experimentation; Lipid Peroxidation; lipide; lipidos; lipids; Male; Malondialdehyde - urine; Medical sciences; orina; oxidacion; oxidation; oxydation; rat; rata; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances - metabolism; urine; Endocrinopathy; Urine; Animal model; Rat; Diabetes mellitus; Reaction product; Rodentia; Dialdehyde; Exploration; Lipids; Vertebrata; Mammalia; Peroxidation
• ISSN: 0024-4201; 1558-9307
• DOI: 10.1007/BF02536063

The effect of streptozotocin‐induced diabetes on the urinary excretion of thiobarbituric acid test‐positive materials was examined. In diabetic rats, urinary excretion of thiobarbituric acid reactive substances was increased 5‐fold over that in nondiabetic animals. High‐performance liquid chromatography of urine samples revealed that five of the six fractions previously found to be increased in vitamin E deficiency [Lee, H.‐S., Shoeman, D.W., and Csallany, A.S. (1992)Lipids 27, 124–128] were also significantly increased in streptozotocin‐induced diabetes. The data suggest that a high level of oxidative stress is induced by uncontrolled diabetes in rats.