Proto-oncogene expression in rabbit aorta after wall injury. First marker of the cellular process leading to restenosis after angioplasty?

• Published in: European heart journal Vol. 13; no. 4; p. 556
• Main Authors: Bauters, C, de Groote, P, Adamantidis, M, Delcayre, C, Hamon, M, Lablanche, J M, Bertrand, M E, Dupuis, B, Swynghedauw, B
• Format: Journal Article
• Language: English
• Published: England 01.04.1992
• Subjects: Angioplasty, Balloon; Animals; Aorta - physiopathology; Cell Division - physiology; Endothelium, Vascular - injuries; Fibromuscular Dysplasia - genetics; Gene Expression Regulation - physiology; Genetic Markers - genetics; Male; Muscle, Smooth, Vascular - injuries; Norepinephrine - physiology; Proto-Oncogene Proteins c-fos - genetics; Proto-Oncogene Proteins c-myc - genetics; Rabbits; Recurrence; RNA, Messenger - genetics
• ISSN: 0195-668X
• DOI: 10.1093/oxfordjournals.eurheartj.a060213

In order to study the earliest phenomenons occurring in the arterial wall after balloon angioplasty, the level of expression of the proto-oncogenes, c-fos and c-myc, was studied in rabbit aorta after balloon denudation by using Northern blot analysis. Both c-fos and c-myc are rapidly and transitorily induced (maximal at 30 min and 2 h after mechanical injury for c-fos and c-myc respectively). By comparison, infusion of norepinephrine increases oncogene expression in normal non-denuded rabbit aorta after 1 h, but the combination of both mechanical and hormonal stimuli do not lead to a more important induction than balloon denudation alone.